Abstract: Carbon tetrachloride (CCl4) has been extensively used in experimental models to demonstrate its hepatotoxic potential. Humans are often exposed to it where it is used in petrol additives, refrigerants, catalyst in polymer formation and in pesticides. In this study, the effect of leaves of Corchorus olitorius L. in CCl4-induced liver damage in male wistar rats was assessed using alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), plasma total protein, superoxide dismutase (SOD), catalase (CAT), glutathione-s-transferase (GST), reduced glutathione (GSH), Packed Cell Volume (PCV), hemoglobin (Hb) and White Blood Cell (WBC) as well as histological assay. Thirty five male wistar rats distributed into seven groups of five rats each were used in this study. The 1 mL kg-1 body weight of CCl4 was administered orally thrice in a week to hepatotoxic groups. Animals in all the groups were either fed control diet or C. olitorius-supplemented diets (COSD). It was observed from the result of this study that exposure to CCl4 and Corchorus olitorius L., produced a significant increase (p<0.05) in ALP activity and plasma total protein in some groups, no significant change (p>0.05) in AST, ALP and SOD activities and a significant decrease (p<0.05) in GST and catalase activities in the non-hepatotoxic groups while GSH increased significantly in all the groups. PCV, Hb and WBC count were not significantly different (p>0.05) and microscopic examination showed severe histological damage in hepatotoxic groups fed with C. olitorius-supplemented diet. These observations indicate that regular consumption of unprocessed C. olitorius L., may further enhance the hepatotoxic potential of CCl4 in humans.