Abstract: Haematological profiles provide important information about the internal environment of a given organism. In this present study, varying concentrations (10, 15, 20 and 25 mg kg-1) of nitrocellulose thinner were orally administered to male albino rats, as single daily dosage for 30 days, to assess the haematological changes associated with oral exposure to solvent. The results showed a significant (p<0.05) dose-dependent decrease in Red Blood Cells (RBC) count, haemoglobin (Hb), Packed Cell Volume (PCV), Mean Corpuscular Volume (MCV), Mean Corpuscular Haemoglobin (MCH), Mean Corpuscular Haemoglobin Concentration (MCHC), neutrophils and increase in total White Blood Cells (WBC), platelets and lymphocytes, compared to the control. However, there was no significant (p>0.05) difference in the changes in the level of these parameters in rats exposed to 10 mg kg-1 when compared to the rats exposed to 15 mg kg-1 and 20 mg kg-1 when compared to the rats exposed to 25 mg kg-1 of the solvent. The results recorded in this present study suggested that exposure to nitrocellulose thinner’s constituents, or their metabolites, may be a risk factor for haematotoxicity in mammals. Hence, the haematotoxic properties of nitrocellulose thinner are reported in the study.