Abstract: The crude extracts of Trianthema decandra L. (Aizoaceae) were studied for the antimicrobial and antioxidant potential. The antimicrobial property of the Trianthema decandra was studied against ten bacterial and two fungal strains using the disc diffusion method and minimum inhibitory concentration were determined for each strain, in which chloroform extract has shown bigger zone of inhibition (18.5 to 23.2 mm) at a concentration level of 1.5 mg disc-1 and MIC at 39 μg mL-1. Control studies with Chloramphenicol and Nystatin 30 μg disc-1 were used as standards for bacteria and fungus, respectively. The anti-oxidant activity was evaluated by DPPH free radical scavenging activity using spectrophotometric method and it was compared with the positive control as Butylated hydroxyl anisole. The total phenolic content was also determined. Total phenolic content was expressed as GAE (gallic acid equivalents) in which, chloroform extract has shown greater amount of GAE. The phytochemical analysis of the extract shows the presence of terpenoids, flavanoids, steroids and saponins.