Abstract: The antioxidant status, Prostate Specific Antigen (PSA) level and hematological parameters in prostatic rats fed leaves of Celosia argentea L. were investigated in this study. A total of twenty five animals were divided into five experimental groups consisting of five animals each. The groups included a Control (C), Negative Control (NC), Positive Control (PC), test I and II. All the groups except C were induced with Benign Prostate Hyperplasia (BPH) by daily injections of testosterone propionate in olive oil. Positive Control (PC) was treated with finasteride. The C, NC and PC groups were fed a normal diet while test I and II were fed 5 and 10% Celosia argentea-Supplemented Diet (CASD), respectively. At the end of the experimental period of twelve weeks, the weights and Prostate Specific Antigen (PSA) of the animals were measured. Antioxidant markers including superoxide dismutase (SOD), glutathione-S-transferase (GST), reduced glutathione (GSH) and catalase (CAT) were determined. Hemoglobin and White Blood Cells (WBC) levels were also determined. A histo-pathological examination of the prostate of the animals in all the groups was carried out. The results obtained showed that PSA levels decreased significantly (p<0.05) in groups fed with CASD. The SOD, GST, CAT and GSH levels increased significantly (p<0.05) in the groups fed CASD. Hemoglobin and WBC levels were increased in the NC and PC groups. The animals in the groups fed with CASD had the highest increase in weight. The histological studies showed a considerable improvement in the prostate histology of the groups fed CASD. These findings indicate that consumption of Celosia argentea-supplemented diets may prevent or suppress the development of BPH in rats.