Abstract: Background and Objective: Transportation causes a high level of stress in cattle. Stress is in terms of blood parameters, growth rate, prone to get diseased and mortality. The present trial aimed to reduce the stress level and death in calves occurred during transportation. Materials and Methods: Natural Oil Blend Formulation (NOBF) was designed and developed by combining the natural oils having immunomodulating and stress-releasing properties. The NOBF applied to claves before and during transportation. The NOBF feed was prepared by mixing 2 kg of NOBF in the regular meal. A total of ten weeks trial was performed on 24 Brahman breeds of the calves. The growth performance was recorded in the form of ADG and FCR. Blood parameters were tested before, during and at the end of the experiment to determine the stress level and health conditions. Data analysis performed using SPSS software. Results: The application of NOBF had enhanced productivity and improved the calves' blood parameters during the transportation and rearing period. The diet of NOBF significantly affected final body weight on day 122. However, it did not affect daily gain (p>0.05). The calves in NOBF treated group obtained 7.78% (12 kg) (p<0.05) higher body weight gain as control during the rearing period. The increase in growth rate had a direct impact on economics, i.e., IDR 540,000 per herd compared to control. Conclusion: The obtained results showed that the application of Natural Oil Blend Formulation (NOBF) supplement had worked significantly reducing the stress in transported calves, which resulted in better blood parameters, better productivity and ultimately higher income.