Abstract: Mastitis is a complex disease; there is no simple solution to control it. It is complex. Mastitis continues as a problem in many dairy herds despite proper application of proven control methods of teat dipping and total dry cow therapy. However, antibiotics were introduced in mastitis therapy from 50 year back for the control of intramammary infection. But the problem in dairy animals remain as same as it was prior to antibiotic era. The antibiotic treatment may help in minimizing the losses but may lead drug resistance. It is much more logical to place the majority of our control efforts by enhancing the immune status of animal. This goal could be achieved by the use of antioxidants such as Vitamin E, Vitamin C, selenium, copper and zinc etc. The mastitic cows have lower Vitamin E and Selenium concentration. The micronutrients being important for proper immune cell function and protection, deficiencies of these micronutrients can have serious consequences on mammary gland health and thus supplementation could provide great benefit to the control of bovine mastitis. Both Vitamin E and Selenium protect cells from the detrimental effect of oxidation but they do so in different ways.