Abstract: Background and Objective: Nutrition has a profound influence on the physiological responses of vital organs in the body of animals. Most of these unconventional feedstuffs have toxic effects on animals. This study investigated the histopathological changes of internal organs and brain regions of rabbits fed sun dried cassava peel meal as a replacement for maize. Materials and Methods: Sixty crossbred weaned rabbits of mixed sexes (30 bucks and 30 does) with an average initial body weight of 559.58±0.42 g/rabbit were used. Twelve rabbits were assigned per treatment in a Completely Randomized Design (CRD) experiment. Cassava peel meal replaced maize at 0, 25, 50, 75 and 100% levels for T1, T2, T3, T4 and T5, respectively. The feeding trial lasted 25 weeks. At the end, the rabbits were slaughtered and internal and male gonads as well as the brain regions were harvested for histopathological assessment. Results: The histopathological changes of the kidney, testis, liver and brain regions revealed the normal histological arrangement of these organs in rabbits fed the control diet (T1) and 25% (T2) cassava peel meal. However, as the level of cassava peel meal replacement increases across treatments, there was a steady rise in tissue degeneration of all organs excluding the brain regions. Tissue abnormality was more pronounced in rabbits fed 75 and 100% cassava peel meal levels. Conclusion: The study concluded that higher replacement levels of cassava peel meal for maize beyond 50% could pose deleterious effects on internal organs of rabbits without any adverse effect on the brain regions.