Two simple, accurate, rapid and sensitive methods were developed for the estimation of Donepezil Hydrochloride (DH) in bulk and tablet formulation. Method A and B describes simple UV spectrophotometric and colorimetric method in methanol, respectively. For method A and method B Î³ max was found to be at 231 and 454 nm, respectively. In method B orange coloured complex was observed due to reaction of keto group of donepezil with 2, 4-dinitrophenyl hydrazine in dilute sulphuric acid. Molar absorptivity of the drug was found to be at 1.38H105 and 3.077H104 for method A and B, respectively. The Beer Lambert`s law was obeyed in the concentration range of 5-40 and 10-60 Î¼g mLG1 for method A and B, respectively.
J.N. Sangshetti, P.R. Mahaparale, S. Paramane and D.B. Shinde, 2008. Spectrophotometric Estimation of Donepezil Hydrochloride in Bulk and Tablet Formulation. Trends in Applied Sciences Research, 3: 109-112.