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Trends in Applied Sciences Research
  Year: 2008 | Volume: 3 | Issue: 1 | Page No.: 109-112
 
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Spectrophotometric Estimation of Donepezil Hydrochloride in Bulk and Tablet Formulation

J.N. Sangshetti, P.R. Mahaparale, S. Paramane and D.B. Shinde

Abstract:
Two simple, accurate, rapid and sensitive methods were developed for the estimation of Donepezil Hydrochloride (DH) in bulk and tablet formulation. Method A and B describes simple UV spectrophotometric and colorimetric method in methanol, respectively. For method A and method B γ max was found to be at 231 and 454 nm, respectively. In method B orange coloured complex was observed due to reaction of keto group of donepezil with 2, 4-dinitrophenyl hydrazine in dilute sulphuric acid. Molar absorptivity of the drug was found to be at 1.38H105 and 3.077H104 for method A and B, respectively. The Beer Lambert`s law was obeyed in the concentration range of 5-40 and 10-60 μg mLG1 for method A and B, respectively.
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How to cite this article:

J.N. Sangshetti, P.R. Mahaparale, S. Paramane and D.B. Shinde, 2008. Spectrophotometric Estimation of Donepezil Hydrochloride in Bulk and Tablet Formulation. Trends in Applied Sciences Research, 3: 109-112.

URL: https://scialert.net/abstract/?doi=tasr.2008.109.112

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