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Trends in Applied Sciences Research

Year: 2008 | Volume: 3 | Issue: 1 | Page No.: 109-112
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Authors

J.N. Sangshetti

P.R. Mahaparale

S. Paramane

D.B. Shinde

Keywords

Research Article

Spectrophotometric Estimation of Donepezil Hydrochloride in Bulk and Tablet Formulation

J.N. Sangshetti, P.R. Mahaparale, S. Paramane and D.B. Shinde
Two simple, accurate, rapid and sensitive methods were developed for the estimation of Donepezil Hydrochloride (DH) in bulk and tablet formulation. Method A and B describes simple UV spectrophotometric and colorimetric method in methanol, respectively. For method A and method B γ max was found to be at 231 and 454 nm, respectively. In method B orange coloured complex was observed due to reaction of keto group of donepezil with 2, 4-dinitrophenyl hydrazine in dilute sulphuric acid. Molar absorptivity of the drug was found to be at 1.38H105 and 3.077H104 for method A and B, respectively. The Beer Lambert`s law was obeyed in the concentration range of 5-40 and 10-60 μg mLG1 for method A and B, respectively.
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J.N. Sangshetti, P.R. Mahaparale, S. Paramane and D.B. Shinde, 2008. Spectrophotometric Estimation of Donepezil Hydrochloride in Bulk and Tablet Formulation. Trends in Applied Sciences Research, 3: 109-112.

URL: https://scialert.net/abstract/?doi=tasr.2008.109.112

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