Aida Zarfeshani
Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia
Mohd Sokhini Abd Mutalib
Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia
Huzwah Khaza`ai
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia
ABSTRACT
It has been reported that a diet enriched in fructose would present animal models used to emulate diabetes mellitus type 2 in human. This study aimed to examine the effect of high fructose induction on the blood glucose, C-reactive protein, interleukin-6, interleukin-4 and body weight among high fructose diet-induced rats. The HFD was induced through drinking water in 21% (w/v) concentration among male Sprague-Dawley rats. The high fructose diet administration was unable to induce hyperglycemia, hypertriglyceridemia or any classic inflammatory markers. Also, no histological inflammation was observed. It was concluded that healthy Sprague-Dawley rats fed high fructose diet for 2.5 months could not develop signs of diabetes mellitus type 2.
PDF References
How to cite this article
Aida Zarfeshani, Mohd Sokhini Abd Mutalib and Huzwah Khaza`ai, 2012. Evaluating of High Fructose Diet to Induce Hyperglycemia and its Inflammatory Complications in Rats. Pakistan Journal of Nutrition, 11: 21-26.
DOI: 10.3923/pjn.2012.21.26
URL: https://scialert.net/abstract/?doi=pjn.2012.21.26
DOI: 10.3923/pjn.2012.21.26
URL: https://scialert.net/abstract/?doi=pjn.2012.21.26
REFERENCES
- Basciano, H., L. Federico and K. Adeli, 2005. Fructose, insulin resistance and metabolic dyslipidemia. Nutr. Metabol., Vol. 2.
CrossRefDirect Link - Berkane, A., F. Tranchida, S. Pietri, M. Culcasi and H. Nguyen et al., 2008. High energy fructose diet induced type 2 diabetes in rats. Atherosclerosis Suppl., 9: 71-71.
CrossRefDirect Link - Fauci, A.S., 2008. Harrison's principles of internal medicine. 17th Edn., McGraw-Hill Medical Publishing, New York, pp: 2958.
Direct Link - Bunnag, P., M.T. Hori, B. Ormsby, M.E. Berger, M.S. Golub and M.L. Tuck, 1997. Impaired in vivo adrenergic responses in diet-induced hypertensive rats. Hypertens. Res., 20: 17-21.
PubMedDirect Link - Carranza, A., C. Mendez, M. Barontini and S. Nowicki, 2004. Insulin enhances l-dopa renal proximal tubule uptake: A regulatory mechanism impaired in insulin esistance. Pflugers Archiv. Eur. J. Physiol., 448: 85-92.
CrossRefDirect Link - Chattopadhyay, S., M. Ramanathan, J. Das and S. Bhattacharya, 1997. Animal models in experimentals diabetes mellitus. Indian J. Exp. Bio., 35: 1141-1145.
PubMedDirect Link - Cho, W., T. Yip, W. Chung, A. Leung, C. Cheng and K. Yue, 2006. Differential expression of proteins in kidney, eye, aorta and serum of diabetic and non-diabetic rats. J. Cell. Biochem., 99: 256-268.
PubMedDirect Link - Crook, M., P. Tutt, H. Simpson and J. Pickup, 1993. Serum sialic acid and acute phase proteins in type 1 and type 2 diabetes mellitus. Clin. Chim. Acta, 219: 131-138.
PubMedDirect Link - Dai, S. and J. McNeill, 1995. Fructose-induced hypertension in rats is concentration-and duration-dependent. J. Pharmacol. Toxicol. Methods, 33: 101-107.
PubMedDirect Link - Dhindsa, S., D. Tripathy, P. Mohanty, H. Ghanim, T. Syed and A. Aljada, 2004. Differential effects of glucose and alcohol on reactive oxygen species generation and intranuclear nuclear factor-κB in mononuclear cells. Metabolism-Clin. Exp., 53: 330-334.
CrossRefPubMedDirect Link - Dimo, T., S.V. Rakotonirina, P.V. Tan, J. Azay, E. Dongo and G. Cros, 2002. Leaf methanol extract of Bidens pilosa prevents and attenuates the hypertension induced by high-fructose diet in Wistar rats. J. Ethnopharmacol., 83: 183-191.
PubMedDirect Link - Fernandez-Real, J., M. Vayreda, C. Richart, C. Gutierrez, M. Broch and J. Vendrell, 2001. Circulating interleukin 6 levels, blood pressure and insulin sensitivity in apparently healthy men and women. J. Clin. Endocrinol. Metab., 86: 1154-1159.
CrossRefDirect Link - Grunfeld, C. and K. Feingold, 1991. The metabolic effects of tumor necrosis factor and other cytokines. Biotherapy, 3: 143-158.
PubMedDirect Link - Halse, R., S. Pearson, J. McCormack, S. Yeaman and R. Taylor, 2001. Effects of tumor necrosis factor-on insulin action in cultured human muscle cells. Diabetes, 50: 1102-1109.
PubMedDirect Link - Hussain, M.J., M. Peakman, H. Gallati, S.S.S. Lo and M. Hawa et al., 1996. Elevated serum levels of macrophage-derived cytokines precede and accompany the onset of IDDM. Diabetologia, 39: 60-69.
PubMedDirect Link - Islas-Andrade, S., M.C.R.R. Monsalve, J.E. de la Pena, A.C. Polanco, M.A. Palomino and A.F. Velasco, 2000. Streptozotocin and alloxan in experimental diabetes: Comparison of the two models in rats. Acta Histochem. Cytochemica, 33: 201-208.
Direct Link - Jain, S.K., J.L. Rains and J.L. Croad, 2007. Effect of chromium niacinate and chromium picolinate supplementation on lipid peroxidation, TNF-α, IL-6, CRP, glycated hemoglobin, triglycerides and cholesterol levels in blood of streptozotocin-treated diabetic rats. Free Radical Biol. Med., 43: 1124-1131.
CrossRef - Jialal, I., S. Devaraj and S.K. Venugopal, 2004. C-reactive protein: Risk marker or mediator in atherothrombosis? Hypertension, 44: 6-11.
Direct Link - Kasim-Karakas, S.E., H. Vriend, R. Almario, L. Chow and M.N. Goodman, 1996. Effects of dietary carbohydrates on glucose and lipid metabolism in Golden Syrian hamsters. J. Lab. Clin. Med., 128: 208-213.
Direct Link - Katakam, P.V.G., M.R. Ujhelyi, M.E. Hoenig and A.W. Miller, 1998. Endothelial dysfunction precedes hypertension in diet-induced insulin resistance. Am. J. Physiol.-Regul., Integr. Comp. Physiol., 275: R788-R792.
Direct Link - Kern, P.A., S. Ranganathan, C. Li, L. Wood and G. Ranganathan, 2001. Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am. J. Physiol.-Endocrinol. Metabol., 280: E745-E751.
Direct Link - Lofgren, P., V. Van Harmelen, S. Reynisdottir, E. Naslund, M. Ryden and S. Rossner, 2000. Secretion of tumor necrosis factor-alpha shows a strong relationship to insulin-stimulated glucose transport in human adipose tissue. Diabetes, 49: 688-692.
PubMedDirect Link - Lee, M., J. Koh, S. Han, K. Ko and S. Kim, 2002. Prevention of autoimmune insulitis by delivery of interleukin-4 plasmid using a soluble and biodegradable polymeric carrier. Pharm. Res., 19: 246-249.
PubMedDirect Link - Mathews, C., W. Suarez-Pinzon, J. Baust, K. Strynadka, E. Leiter and A. Rabinovitch, 2005. Mechanisms underlying resistance of pancreatic islets from ALR/Lt mice to cytokine-induced destruction. J. Immunol., 175: 1248-1256.
PubMedDirect Link - Matsuzaki, T., A. Takagi, H. Ikemura, T. Matsuguchi and T. Yokokura, 2007. Intestinal microflora: Probiotics and autoimmunity. J. Nutr., 137: 798-802.
Direct Link - Mohanty, P., W. Hamouda, R. Garg, A. Aljada, H. Ghanim and P. Dandona, 2000. Glucose challenge stimulates Reactive Oxygen Species (ROS) generation by leucocytes. J. Clin. Endocrinol. Metab, 85: 2970-2973.
CrossRefPubMedDirect Link - Pradhan, A.D., J.E. Manson, N. Rifai, J.E. Buring and P.M. Ridker, 2001. C-reactive protein, interleukin 6 and risk of developing type 2 diabetes mellitus. J. Am. Med. Assoc., 286: 327-334.
CrossRefDirect Link - Raz, I., R. Eldor and Y. Naparstek, 2005. Immune modulation for prevention of type 1 diabetes mellitus. Trends Biotechnol., 23: 128-134.
PubMedDirect Link - Rodriguez-Moran, M. and F. Guerrero-Romero, 1999. Increased levels of C-reactive protein in noncontrolled type II diabetic subjects. J. Diabetes Complications, 13: 211-215.
Direct Link - Singh Devaraj, U. and I. Jialal, 2005. Vitamin E, oxidative stress and inflammation. Ann. Rev. Nutr., 25: 151-174.
Direct Link - Stark, A., B. Timar and Z. Madar, 2000. Adaption of Sprague dawley rats to long-term feeding of high fat of high fructose diets. Eur. J. Nutr., 39: 229-234.
PubMedDirect Link - Suzuki, M., C. Nomura, H. Odaka and H. Ikeda, 1997. Effect of an insulin sensitizer, pioglitazone, on hypertension in fructose-drinking rats. Jap. J. Pharmacol., 74: 297-302.
PubMedDirect Link - Thorburn, A.W., L.H. Storlien, A.B. Jenkins, S. Khouri and E.W. Kraegen, 1989. Fructose-induced in-vivo insulin resistance and elevated plasma triglyceride levels in rats. Am. J. Clin. Nutr., 49: 1155-1563.
PubMedDirect Link - Tobey, T.A., C.E. Mondon, I. Zavaroni and G.M. Reaven, 1982. Mechanism of insulin resistance in fructose-fed rats. Metabolism, 31: 608-612.
PubMedDirect Link - Vrana, A. and L. Kazdova, 1986. Effects of dietary sucrose or fructose on carbohydrate and lipid metabolism. Animal studies. Animal studies. Prog. Biochem. Pharmacol., 21: 59-73.
PubMedDirect Link - Wellen, K.E. and G.S. Hotamisligil, 2005. Inflammation, stress and diabetes. J. Clin. Invest., 115: 1111-1119.
CrossRefDirect Link - Yadav, H., S. Jain and P. Sinha, 2007. Antidiabetic effect of probiotic dahi containing Lactobacillus acidophilus and Lactobacillus casei in high fructose fed rats. Nutrition, 23: 62-68.
PubMedDirect Link - Zavaroni, I., Y.D. Chen and G.M. Reaven, 1982. Studies of the mechanism of fructose-induced hypertriglyceridemia in the rat. Metabolism, 31: 1077-1083.
PubMedDirect Link