Sh. Jalili
Department of Biology,
Faculty of Science,
Urmia University,
Iran
M. Ilkhanipour
Department of Biology,
Faculty of Science,
Urmia University,
Iran
R. Heydari
Department of Biology,
Faculty of Science,
Urmia University,
Iran
S. Salehi
Department of Biology,
Faculty of Science,
Urmia University,
Iran
A.A. Farshid
Faculty of Veterinary Medicine, Urmia University, Iran
ABSTRACT
Endosulfan, an organochlorine insecticide and acaricide, has been used in agriculture for several years. The aim of present study was to analyze the cardiotoxic effect of endosulfan which caused biochemical changes in heart of male rats and to evaluate the possible protective effect of vitamin E. Vitamin E (200mg/kg, twice a week), endosulfan (2mg/kg per day, once a day in corn oil) and Vitamin E (200mg/kg, twice a week) + endosulfan (2mg/kg per day, once a day in corn oil) combination were given to rats (n=6) orally via gavage for 4 weeks. GPx and CAT activities were measured in tissues samples. Gpx, CAT and SOD activities increased in the endosulfan - treated group heart tissues compared to control group (P<0.01, P<0.05 and P<0.01 respectively). GPx and SOD activities decreased in the endosulfan+vitamin E - treated group compared to endosulfan - treated group (P<0.05). Decrease of CAT activity was not significant in the endosulfan+vitamin E - treated group compared to endosulfan - treated group. We conclude that vitamin E significantly reduces endosulfan - induced oxidative stress in rat heart.
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How to cite this article
Sh. Jalili, M. Ilkhanipour, R. Heydari, S. Salehi and A.A. Farshid, 2007. The Effects of Vitamin E on Endosulfan - Induced Oxidative Stress in Rat Heart. Pakistan Journal of Nutrition, 6: 375-380.
DOI: 10.3923/pjn.2007.375.380
URL: https://scialert.net/abstract/?doi=pjn.2007.375.380
DOI: 10.3923/pjn.2007.375.380
URL: https://scialert.net/abstract/?doi=pjn.2007.375.380