Donatien Gatsing
Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Cameroon
James A. Mbah
Department of Chemistry, Faculty of Science, University of Buea, P.O. Box 63 Buea, Cameroon
Ibrahim H. Garba
Chemistry Programme, School of Science, Abubakar Tafawa Balewa University, PMB 0248 Bauchi, Nigeria
Pierre Tane
Department of Chemistry, Faculty of Science, University of Dschang,
P.O. Box 67 Dschang, Cameroon
Pierre Djemgou
Department of Chemistry, Faculty of Science, University of Dschang,
P.O. box 67 Dschang, Cameroon
Bridget F. Nji-Nkah
Department of Animal Production, Faculty of Agronomy and Agricultural Sciences, University of Dschang, P.O. Box 222 Dschang, Cameroon
ABSTRACT
Three homogentisic acid derivatives, namely methyl 2-(1`β-geranyl-5`β-hydroxy-2`-oxocyclohex-3`-enyl)acetate (1), 2-(1`β-geranyl-5`β-hydroxy-2`-oxocyclohex-3`-enyl)acetic acid (2), methyl 2-(1`β-geranyl-5`β-hydroxy-4`β-methoxy-2`-oxocyclohexyl)acetate (3), isolated from the leaves of Glossocalyx brevipes, were screened for antisalmonellal activity using both agar diffusion and broth dilution techniques. Only compound 2 showed significant antimicrobial activity against Salmonella typhi (26 mm), Salmonella paratyphi A (23 mm) and Salmonella paratyphi B (22 mm). The MIC (minimum inhibitory concentration) and MBC (minimum bactericidal concentration) values were 10 and 80 μg mL-1, respectively, against all the three bacteria strains used. These data support the use of Glossocalyx brevipes in anti-typhoid preparations.
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How to cite this article
Donatien Gatsing, James A. Mbah, Ibrahim H. Garba, Pierre Tane, Pierre Djemgou and Bridget F. Nji-Nkah, 2006. An Antisalmonellal Agent from the Leaves of Glossocalyx brevipes Benth (Monimiaceae). Pakistan Journal of Biological Sciences, 9: 84-87.
DOI: 10.3923/pjbs.2006.84.87
URL: https://scialert.net/abstract/?doi=pjbs.2006.84.87
DOI: 10.3923/pjbs.2006.84.87
URL: https://scialert.net/abstract/?doi=pjbs.2006.84.87
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