Karamat Mozafari Nia
Department of Ear,
Nose and Throat (EXT),
Shafa Hospital,
Kennan Physiology Research
Center, University of Medical Sciences, Kennan, Iran
Seyamak Salehi
Department of Ear,
Nose and Throat (EXT),
Shafa Hospital,
Kennan Physiology Research
Center, University of Medical Sciences, Kennan, Iran
ABSTRACT
Circulating concentrations of Insulin-Like Growth Factor-1 (IGF-1) and Insulin-Like Growth Factor Binding Protein 3 (IGFBP3) are strongly related to diurnal GH secretion, reflecting mean daily serum GH levels. This interventional experiment studied serum levels of IGF-1 and IGFBP3 of 30 boys of 3-8-years old with grade 3 and 4 adenotonsillar hypertrophy before and after adenotonsillectomy (T and A surgery). Fasting levels of serum growth hormone biochemical markers (IGF-1 and IGFBP3) were measured on the morning of T and A surgery and 4-5 months postoperatively. IGF-1 and IGFBP3 serum levels were significantly increased in these patients after T and A surgery (p<0.01). Therefore Grade 3 and 4 adenotonsillar hypertrophy could be considered as major factors for prompts reduction of both IGF-1 and GIFBP3.
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How to cite this article
Karamat Mozafari Nia and Seyamak Salehi, 2008. Evaluation of Changes in Serum Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein 3 in Children with Adenotonsillar Hypertrophy Before and After Surgery. Journal of Medical Sciences, 8: 148-151.
DOI: 10.3923/jms.2008.148.151
URL: https://scialert.net/abstract/?doi=jms.2008.148.151
DOI: 10.3923/jms.2008.148.151
URL: https://scialert.net/abstract/?doi=jms.2008.148.151
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