S.B. Pajovi
Laboratory for Molecular Biology and Endocrinology, Vin ta Institute for Nuclear Sciences, P. O. Box 522, 1 1001 Belgrade, Yugoslavia
G. Joksi
Laboratory for Molecular Biology and Endocrinology, Vin ta Institute for Nuclear Sciences, P. O. Box 522, 1 1001 Belgrade, Yugoslavia
S. Peji
Laboratory for Molecular Biology and Endocrinology, Vin ta Institute for Nuclear Sciences, P. O. Box 522, 1 1001 Belgrade, Yugoslavia
J. Kasapovi
Laboratory for Molecular Biology and Endocrinology, Vin ta Institute for Nuclear Sciences, P. O. Box 522, 1 1001 Belgrade, Yugoslavia
G. Cuttone
Southern National Laboratory,
Via S. Sofia 44, 951 23 Catania, Italy
L. Masotti
Department of Biochemistry G. Moruzzi
University of Bologna, Via Irnerio, 48-401 26 Bologna, Italy
ABSTRACT
The research work was conducted to investigate the changes of superoxide dismutases (SODs) activity in human blood cells irradiated with 22.6 MeV protons, and to compare the results with examinations performed with x- and γ- rays. The activity of SOD was significantly lowered after 1 Gy of proton beam and increase of dose further decreases total SOD activity. The effect of proton beam is same in the cases of cytosol SOD (CuZnSOD) and mitochondrial SOD (MnSOD), which means that both defense lines are disturbed already after 1Gy proton beam irradiation, which is very important in the radio therapy of tumor cells. This dose response is compared to dose of x- or γ - irradiation, the difference is obvious. The increased MnSOD activity is induced by in vitro irradiation with 2 Gy of x - rays and after 4 Gy of MnSOD activity is on the control level again. The measured activity of mitochondrial SOD shows that the most striking fall after irradiation with 3 Gy or 4 Gy of γ-rays.
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How to cite this article
S.B. Pajovi, G. Joksi, S. Peji, J. Kasapovi, G. Cuttone and L. Masotti, 2001. Antioxidant Dose Response in Human Blood Cells Exposed to Different Types of Irradiation. Journal of Medical Sciences, 1: 133-136.
DOI: 10.3923/jms.2001.133.136
URL: https://scialert.net/abstract/?doi=jms.2001.133.136
DOI: 10.3923/jms.2001.133.136
URL: https://scialert.net/abstract/?doi=jms.2001.133.136
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