Seda Balkan
Department of Biology, Faculty of Science and Art, Trakya University, 22080 Edirne, Turkey
Tulin Aktac
Department of Biology, Faculty of Science and Art, Trakya University, 22080 Edirne, Turkey
ABSTRACT
The present study investigated the toxic effect of benomyl on the liver functions of the rats. Benomyl was administered at 200 mg kg 1 per day dose gavage to male and female rats (Spraque Dawley) for 5 days. Body weights, organ weights, biochemical and haemotological parameters and histological changes to the liver of rats were investigated. Body weights were not changed significantly but female and male liver weights, male spleen and liver weights were increased. Red blood cells (RBC), hemoglobin (HGB) and haematocrit (HCT) values were decreased in male and female rats which were treated with benomyl but white blood cells (WBC) and thrombocytes (PLT) values were not significantly different from controls. In the male rats, alanin aminotransferase (ALT), alcaline phosphatase (ALP), creatine phosphokinase izozyme (CK-MB) and amylase (AMYL) activities were changed. Also, in the female rats, alanin aminotransferase (ALT), aspartat aminotransferase (AST), creatine phosphokinase izozyme (CK-MB), amylase (AMYL) and lactat dehydrogenase (LDH) activities were changed. There was no significant change in serum gamma glutamyl transferase (GGT) levels of male and female rats. Therefore, it might indicate that benomyl has not carcinogenic effect in rats. Histopathological examinations revealed the cytoplasmic vacuolisation, enlargement of sinüsoids, picnotic nuclei, disintegrated membrans and degeneration of the blood vessel endothelium.
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How to cite this article
Seda Balkan and Tulin Aktac, 2005. Study on the Liver Functions in Rats Exposed to Benomyl. Journal of Biological Sciences, 5: 666-669.
DOI: 10.3923/jbs.2005.666.669
URL: https://scialert.net/abstract/?doi=jbs.2005.666.669
DOI: 10.3923/jbs.2005.666.669
URL: https://scialert.net/abstract/?doi=jbs.2005.666.669
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