F. O. Obi
National Research Centre, Plant Nutrition Department, Dokki, Cairo, Egypt
H.C.C. Maduka
Department of Biochemistry, College of Medical Sciences, University of Maiduguri, Barno State, Nigeria
Y.P. Mamza
Kidney Centre, University of Maiduguri Teaching Hospital,
Maiduguri, Barno State, Nigeria
ABSTRACT
The effect of treatment with chloroquine and normal saline on blood glucose and serum cholesterol levels was investigated in alloxan-induced diabetic and non-diabetic rabbits. It was observed that high dose of chloroquine (25 mg kg‾1 body wt) administration twice daily for three consecutive days led to an increase in the blood glucose and decrease in the serum cholesterol levels. The possible mechanism for the hyperglycaemic and hypocholesterolemic effects being observed was x-rayed in the light of other reported observations of chloroquine administration.
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How to cite this article
F. O. Obi, H.C.C. Maduka and Y.P. Mamza, 2003. Effect of Chloroquine on Blood Glucose and Cholesterol Levels in Alloxan-induced Diabetic Rabbits. Journal of Biological Sciences, 3: 875-881.
DOI: 10.3923/jbs.2003.875.881
URL: https://scialert.net/abstract/?doi=jbs.2003.875.881
DOI: 10.3923/jbs.2003.875.881
URL: https://scialert.net/abstract/?doi=jbs.2003.875.881
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