Khurram Shahzad
Department of chemistry, University of Agriculture, Faisalabad 38090, Pakistan
Muhammad Shahid
Department of chemistry, University of Agriculture, Faisalabad 38090, Pakistan
Munir A.Shiekh
Department of chemistry, University of Agriculture, Faisalabad 38090, Pakistan
Zahid Mehmood
Department of chemistry, University of Agriculture, Faisalabad 38090, Pakistan
H. Zubair
Department of chemistry, University of Agriculture, Faisalabad 38090, Pakistan
ABSTRACT
The Biodisposition of Ciprofloxacin was investigated in 10 healthy male volunteers after an oral administration of 250 mg tablet. Antibiotic concentration was measured by UV spectrophotometer. The kinetic parameters were calculated after performing one compartment model analysis. The absorption half-life and biological half-life showed Mean ± SD values of 1.068 ± 0.295 and 1.451 ± 0.516 h the apparent volumes of distribution of Ciprofloxacin were found 28.59±6.6 liters. The average value of absorption rate constant was 0.625±0.519 h-1. The mean ± SD value of MRT was 3.903 ± 0.802 h total body clearance ranged between 11.13 to 22.48 with mean ± SD value of 14.33±3.19 l h-1. These values deviate from the literature values emphasizing that such kind of studies must be conducted in local populations so that an appropriate dosage can prescribed.
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How to cite this article
Khurram Shahzad, Muhammad Shahid, Munir A.Shiekh, Zahid Mehmood and H. Zubair, 2003. Biodisposition Kinetics of Ciprofloxacin in Male Human Volunteers Following Oral Administration. Journal of Biological Sciences, 3: 43-47.
DOI: 10.3923/jbs.2003.43.47
URL: https://scialert.net/abstract/?doi=jbs.2003.43.47
DOI: 10.3923/jbs.2003.43.47
URL: https://scialert.net/abstract/?doi=jbs.2003.43.47
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