Sheikh Arshad Saeed
Department of Biological and Biomedical Sciences, The Aga Khan University, Stadium Road, Karachi-74800, Pakistan
Sarah Khalid Khan
Department of Biological and Biomedical Sciences, The Aga Khan University, Stadium Road, Karachi-74800, Pakistan
Saira Abdul Aziz Samani
Department of Biological and Biomedical Sciences, The Aga Khan University, Stadium Road, Karachi-74800, Pakistan
Kashfa Farhat
Department of Biological and Biomedical Sciences, The Aga Khan University, Stadium Road, Karachi-74800, Pakistan
Natasha Imtiaz Hansraj
Department of Biological and Biomedical Sciences, The Aga Khan University, Stadium Road, Karachi-74800, Pakistan
Asthma Mushir Ahmad Khan
Department of Biological and Biomedical Sciences, The Aga Khan University, Stadium Road, Karachi-74800, Pakistan
Ameer Zaigham Rasheed
Department of Biological and Biomedical Sciences, The Aga Khan University, Stadium Road, Karachi-74800, Pakistan
Abdul Mueed Zafar
Department of Biological and Biomedical Sciences, The Aga Khan University, Stadium Road, Karachi-74800, Pakistan
Muhammad Ameen Rauf
Department of Biological and Biomedical Sciences, The Aga Khan University, Stadium Road, Karachi-74800, Pakistan
Sagheer Ahmad
Department of Biological and Biomedical Sciences, The Aga Khan University, Stadium Road, Karachi-74800, Pakistan
ABSTRACT
Blood plasma was found to contain endogenous inhibitor of prostaglandin (PG) synthase (EIPS) and this activity was associated with at least two plasma components, albumin and haptoglobin. Hemoglobin, a stimulant of PG biosynthesis which is bound by haptoglobin, reversed the inhibitory effect of haptoglobin and reduced the inhibition by albumin, acetylsalicylate or indomethacin. It is proposed that in physiological situations the albumin-associated EIPS mainly helps to prevent excessive PG production, whereas in tissue injury the acute phase protein haptoglobin plays a more important role. Possible clinical applications of EIPS are discussed.
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Sheikh Arshad Saeed, Sarah Khalid Khan, Saira Abdul Aziz Samani, Kashfa Farhat, Natasha Imtiaz Hansraj, Asthma Mushir Ahmad Khan, Ameer Zaigham Rasheed, Abdul Mueed Zafar, Muhammad Ameen Rauf and Sagheer Ahmad, 2003. The Inhibition of Prostaglandin Biosynthesis by Human Plasma and its Relationship to Albumin and Haptoglobin. Journal of Biological Sciences, 3: 1188-1202.
DOI: 10.3923/jbs.2003.1188.1202
URL: https://scialert.net/abstract/?doi=jbs.2003.1188.1202
DOI: 10.3923/jbs.2003.1188.1202
URL: https://scialert.net/abstract/?doi=jbs.2003.1188.1202
REFERENCES
- Saeed, S.A., M. Drew and H.O.J. Collier, 1980. Endogenous inhibitors of lipoxygenase. Eur. J. Pharmacol., 67: 169-170.
PubMedDirect Link - Saeed, S.A., W.J. McDonald-Gibson, J. Cuthbert, J.L. Copas and C. Scheider et al., 1977. Endogenous inhibitor of prostaglandin synthetase. Nature, 270: 32-36.
CrossRefDirect Link - Ubatuba, F.B., 1973. The use of the hamster stomach in vitro as an assay preparation for prostaglandins. Br. J. Pharmacol., 49: 662-666.
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