Akin Pala
�anakkale Onsekiz Mart University,
Faculty of Agriculture, Department of Animal Science, 1 7100, �anakkale, Turkey
ABSTRACT
A dominant mutation at the agouti locus on mouse chromosome 2 is a promoter of overeating and increased linear growth. Agouti related protein, which can be produced using bacteria can be used to reproduce the same growing effect. Androgens are known to promote leanness and increased growth. Combined effects of testosterone and agouti may provide fast growing-lean animals.
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How to cite this article
Akin Pala, 2003. Effects of Agouti Related Protein and Androgens on Growth. Journal of Applied Sciences, 3: 197-202.
DOI: 10.3923/jas.2003.197.202
URL: https://scialert.net/abstract/?doi=jas.2003.197.202
DOI: 10.3923/jas.2003.197.202
URL: https://scialert.net/abstract/?doi=jas.2003.197.202
REFERENCES
- Arnold, A.M., J.M. Peralta and M.L. Thonney, 1997. Effects of testosterone on differential muscle growth an on protein and nucleic acid concentrations in muscles of growing lambs. J. Anim. Sci., 75: 1495-1503.
Direct Link - Bergen, H.T., T.M. Mizuno, J. Taylor and C.V. Mobbs, 1998. Hyperphagia and weight gain after gold-thioglucose: Relation to hypothalamic neuropeptide Y and proopiomelanocortin. Endocrinology, 139: 4483-4488.
CrossRefDirect Link - Blanchard, S.G., C.O. Harris, O.R. Ittoop, J.S. Nichols, D.J. Parks, A.T. Truesdale and W.O. Wilkison, 1995. Agouti antagonism of melanocortin binding and action in the B16F10 murine melanoma cell line. Biochem., 34: 10406-10411.
Direct Link - Boston, B.A., K.M. Blaydon, J. Varnerin and R.D. Cone, 1997. Independent and additive effects of central POMC and leptin pathways on murine obesity. Sci., 278: 1641-1644.
Direct Link - Bultma, S.J., E.J. Michaud and R.P. Woychik, 1992. Molecular characterization of the mouse agouti locus. Cell, 71: 1195-1204.
Direct Link - De-Wied, D. and J. Jolles, 1982. Neuropeptides derived from pro-opiocortin: Behavioral, physiological and neurochemical effects. Physiol. Rev., 62: 976-1059.
Direct Link - Fan, W., B.A. Boston, R.A. Kesterson, V.J. Hruby and R.D. Cone, 1997. Melanocortinergic inhibition of feeding behavior and disruption with an Agouti-mimetic. Nature, 9: 165-168.
Direct Link - Florini, J.R., 1970. Effects of testosterone on qualitative pattern of protein synthesis in skeletal muscle. Biochemistry, 9: 909-912.
CrossRef - Himms-Hagen, J., 1985. Brown adipose tissue metabolism and thermogenesis. Annu. Rev. Nutr., 5: 69-94.
CrossRef - Huszar, D., C.A. Lynch, V. Fairchild-Huntress, J.H. Dunmore and Q. Fang et al., 1997. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell, 88: 131-141.
CrossRefDirect Link - Leibel, R.L., W.K. Chung and S.C. Chua, 1997. The molecular genetics of rodent single gene obesities. J. Biol. Chem., 272: 31937-31940.
Direct Link - Lu, D., D. Willard, I.R. Patel, S. Kadwell, and L. Overton et al., 1994. Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature, 371: 799-802.
CrossRef - Manne, J., A.C. Argeson and L.D. Siracusa, 1995. Mechanisms for the pleiotropic effects of the agouti gene. Proc. Nat. Acad. Sci. USA., 92: 4721-4724.
Direct Link - Mooradian, A.D., J.E. Morley and S.G. Korenman, 1987. Biological actions of androgens. Endocrine Rev., 8: 1-28.
CrossRefDirect Link - Mulvaney, D.R., D.N. Marple and R.A. Merkel, 1988. Proliferation of skeletal muscle satellite cells after castration and administration of testosterone propionate. Proc. Soc. Exp. Biol. Med., 188: 40-45.
Direct Link - Ollmann, M.M., B.D. Wilson, Y.K. Yang, J.A. Kerns, Y. Chen, I. Gantz and G.S. Barsh, 1997. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science, 278: 135-138.
Direct Link - Ollmann, M.M., M.L. Lamoreux, B.D. Wilson and G.S. Barsh, 1998. Interaction of Agouti protein with the melanocortin 1 receptor in vitro and in vivo. Genes Dev., 12: 316-330.
Direct Link - Palmiter, R.D., J.C. Erickson, G. Hollopeter, S.C. Baraban and M.W. Schwartz, 1998. Life without neuropeptide Y. Recent Prog. Horm. Res., 53: 163-199.
Direct Link - Poole, T.W. and W.K. Silvers, 1976. An experimental analysis of the recessive yellow coat color mutant in the mouse. Dev. Biol. Feb., 48: 377-381.
Direct Link - Rooyackers, O.E. and K.N. Sreekumaran, 1997. Hormonal regulation of human muscle protein metabolism. Annu. Rev. Nutr., 17: 457-485.
Direct Link - Rosenfeld, R.D., L. Zeni, A.A. Welcher, L.O. Narhi and C. Hale et al., 1998. Biochemical, biophysical and pharmacological characterization of bacterially expressed human agouti-related protein. Biochemistry, 37: 16041-16052.
CrossRefPubMedDirect Link - Shutter, J.R., M. Graham, A.C. Kinsey, S. Scully, R. Luthy and K.L. Stark, 1997. Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. Genes Dev., 11: 593-602.
Direct Link - Siegrist, W., R. Drozdz, R. Cotti, D.H. Willard, W.O. Wilkison and A.N. Eberle, 1997. Interactions of alpha-melanotropin and agouti on B16 melanoma cells: Evidence for inverse agonism of agouti. J. Recept Signal Transduct Res., 17: 75-98.
Direct Link - Willard, D.H., W. Bodnar, C. Harris, L. Kiefer and J.S. Nichols et al., 1995. Agouti structure and function: Characterization of a potent alpha-melanocyte stimulating hormone receptor antagonist. Biochemistry, 34: 12341-12356.
Direct Link - Yang, Y.K., M.M. Ollmann, B.D. Wilson, C. Dickinson, T. Yamada, G.S. Barsh and I. Gantz, 1997. Effects of recombinant agouti-signaling protein on melanocortin action. Mol. Endocrinol., 11: 274-280.
Direct Link - Yen, T.T., A.M. Gill, L.G. Frigeri, G.S. Barsh and G.L. Wolff, 1994. Obesity, diabetes and neoplasia in yellow A(vy)/- mice: Ectopic expression of the agouti gene. FASEB. J., 8: 479-488.
Direct Link