Rifat -uz- Zaman
Department of Pharmacy, Islamia University, Bahawalpur, Pakistan
Muhammad Shoaib Akhtar
Faculty of Veterinary Sciences, University of Agriculture, Faisalabad, Pakistan
Muhammad Shafiq Khan
Department of Pharmacy, Islamia University, Bahawalpur, Pakistan
ABSTRACT
Polygonum viviparum, root has been used in the folkloric medicine for the treatment of a many diseases including gastrointestinal disorders. Powdered roots of Polygonum viviparum (PV) and its aqueous (PV-A) and ethanol (PV-E) extracts were evaluated for anti-ulcerogenic efficacy in rats with ulcer lesions in the glandular stomach induced by indomethacin (25 mg kg-1)subcutaneously, to rationalize the folkloric uses. The pretreatment of PV protected the experimental rats against gastric changes caused by indomethacin in a dose-dependent manner. PV-A and PV-E extracts (equivalent to 2.0 g kg-1) of the powder also inhibited the indomethacin-induced effects on gastric juice volume, pH, acid-output and ulcer index. PV, PV-A and PV-E showed highly significantly in vitro acid buffering and pepsin binding activities. The data indicates that PV and its extracts protect the gastric mucosa against indomethacin-induced gastric changes, may result from their lipid peroxidation/apoptosis inhibition.
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How to cite this article
Rifat -uz- Zaman, Muhammad Shoaib Akhtar and Muhammad Shafiq Khan, 2005. Protective Effects of Polygonum viviparum L. Root and its Extracts Against
Lipid-peroxidation Induced by Indomethacin in Rats. International Journal of Pharmacology, 1: 324-328.
DOI: 10.3923/ijp.2005.324.328
URL: https://scialert.net/abstract/?doi=ijp.2005.324.328
DOI: 10.3923/ijp.2005.324.328
URL: https://scialert.net/abstract/?doi=ijp.2005.324.328
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