Maria Traykova
Department of Pharmacology and Toxicology, Medical University, 2 Zdrave St., 1431 Sofia, Bulgaria
Irena Kostova
Department of Chemistry, Faculty of Pharmacy, Medical University, 2 Dunav St., Sofia 1000, Bulgaria
ABSTRACT
Coumarins, an old class of natural and synthetic benzopyrene derivatives, attract an intense interest because of their diverse pharmacological use. The biochemical properties and therapeutic applications of simple coumarins strongly depend upon the molecular structure of these compounds. Recently their antioxidant effects were extensively examined in connection with possibilities for control over the oxidative stress. Latter is being implicated in many diseases curable by therapy with coumarin-containing drugs. In this review, experimental data for antioxidant properties of coumarins are presented. It was observed that different coumarins may act as antioxidants by scavenging free radicals, by acting as enzymes modulators and by bonding free metal cations in helate complexes. The antioxidant activities are discussed in relation with their molecular structure.
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How to cite this article
Maria Traykova and Irena Kostova, 2005. Coumarin Derivatives and Oxidative Stress. International Journal of Pharmacology, 1: 29-32.
DOI: 10.3923/ijp.2005.29.32
URL: https://scialert.net/abstract/?doi=ijp.2005.29.32
DOI: 10.3923/ijp.2005.29.32
URL: https://scialert.net/abstract/?doi=ijp.2005.29.32
REFERENCES
- Roth, E., 1997. Oxygen free radicals and their clinical implications. Acta Chir. Hung., 36: 302-305.
PubMedDirect Link - Droge, W., 2002. Free radicals in the physiological control of cell function. Phsyol. Rev., 82: 47-95.
CrossRefPubMedDirect Link - Sites, H., 1993. Strategies in antioxidant defense. Eur. J. Biochem., 215: 213-219.
PubMedDirect Link - Stamler, J.S., D.J. Singel and J. Loscalzo, 1992. Biochemistry of nitric oxide and its redox-activated forms. Science, 258: 1898-1902.
CrossRefDirect Link - Palmer, R., D. Rees, D. Ashton and S. Moncada, 1988. L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation. Biochem. Biophys. Res. Commun., 153: 1251-1256.
PubMedDirect Link - Hoult, J.R.S. and M. Paya, 1996. Pharmacological and Biochemical actions of simple coumarins: Natural products with therapeutic potential. Gen. Pharmacol.: Vasc. Syst., 27: 713-722.
CrossRefDirect Link - Yang, Q., M. Hergenhahn, A. Weininger and H. Bartsh, 1999. Cigarette smoke induces direct DNA damage in the human B limphoid cell line Raji. Carcinogenesis, 20: 1769-1775.
Direct Link - Khan, N., S. Sharma and S. Sultana, 2004. Attenuation of potasium bromide-induced nephrotoxicity by coumarin (1,2-benzopyrone) in Wistar rats: Chemoprevention against free-radical mediated renal oxidative stress and tumor promotion response. Redox Rep., 9: 19-28.
Direct Link - McMachon, M., K. Itoh, M. Yamamoto, S. Chanas and L. McLellan et al., 2001. The capn collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. Cancer Res., 61: 3299-32307.
- Baccard, N., H. Mechiche, P. Hasoyrollas, L. Manot, D. Lamiable, P. Devilier and H. Millard, 2000. Effect of 7-hydroxycoumarin on isolated perfused and ischemic-reperfused rat heart. Arzeimittelforschung, 50: 890-896.
Direct Link - Arora, A., M.G. Nair and G.M. Strasburg, 1998. Structure-activity relationships for antioxidant activities of a series of flavonoids in a liposomal system. Free Radic. Biol. Med., 24: 1355-1363.
CrossRefDirect Link - Masamoto, Y., H. Ando, Y. Murata, Y. Shimoishi, M. Tada and K. Takahata, 2003. Mushroom tyrosinase inhibitory activity of esculetin isolated from seeds of Euphorbia lathyris L. Biosci. Biotechnol. Biochem., 67: 631-634.
CrossRefPubMedDirect Link - Sekiya, K, H. Okuda and S. Arichi, 1982. Selective inhibition of platelet lipoxygenase by esculetin. Biochem. Biophys. Acta, 713: 68-72.
PubMedDirect Link - Raj, H.G., V.S. Parmar, S.C. Jain, S. Goel and S. Malhotra et al., 1998. Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part I: Dioxygenated 4-methyl coumarins as superb antioxidant and radical scavenging agents. Bioorganic Med. Chem., 6: 833-839.
CrossRefDirect Link - Raj, H.G., S.K. Sharma, B.S. Garg, V.S. Parmar and S.C. Jain et al., 1998. Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 3: A novel mechanism for the inhibition of biological membrane lipid peroxidation by deoxygenated 4-methylcoumarins mediated by the formation of a stable ADP-Fe-inhibitor mixed ligand complex. J. Bioorganic Med. Chem., 6: 2205-2212.
Direct Link - Fernandez-Puntero, B., I. Barroso, I. Iglesias, J. Benedi and A. Villar, 2001. Antioxidant activity of fraxetin: in vivo and ex vivo parameters in normal situation versus induced stress. Biol. Pharm. Bull., 24: 777-784.
Direct Link - Vladimirov, Y., E. Parfenov, O. Epashintseva, V. Sharov, E. Dremina and L. Smirnov, 1992. Antiradical activity of complec Copper (II) compounds on coumarin ligand base. Bull. Eksp Biol. MED., 113: 479-481.
PubMedDirect Link - Vladimirov, U.A, E.A. Parfenov, O.M. Epanchintseva and L.N. Smirnov, 1991. Antiradical activity of 3-substituted coumarins and their effect on iron-dependent chemiluminescence. Biull. Eksp Biol. Med., 112: 358-360.
CrossRefPubMedDirect Link