Mohammed H. Al-Nazawi
Department of Physiology, Biochemistry and Pharmacology,
College of Veterinary Medicine and Animal Resources, King Faisal University, P.O. Box 3498, Al-Ahsa 31982, Saudi Arabia
ABSTRACT
The pharmacokinetics and tolerance of thiamphenicol (TAP) were investigated in camel and sheep following administration of intravenous dose of 20 mg kg -1 body weight. The disposition kinetic of TAP in camel and sheep showed a biexponential profile with elimination half-live of 2.11 h for camel and 1.5 h for sheep and volume of distribution of 1.1 L kg -1 for camel and 0.90 L kg -1 for sheep indicating extensive tissue penetration which is consistent with TAP lipophilicity. The drug administered at a dose of 40 mg kg -1 to camel and sheep produced no changes in haematological and plasma biochemical parameters suggesting that both species can tolerate higher doses of the drug.
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How to cite this article
Mohammed H. Al-Nazawi, 2005. Pharmacokinetics and Tolerance of Thiamphenicol in Camels and Sheep. International Journal of Pharmacology, 1: 25-28.
DOI: 10.3923/ijp.2005.25.28
URL: https://scialert.net/abstract/?doi=ijp.2005.25.28
DOI: 10.3923/ijp.2005.25.28
URL: https://scialert.net/abstract/?doi=ijp.2005.25.28
REFERENCES
- Bennett, J.V., J.L. Brodie, E.J. Benner and W.M.M. Kirby, 1966. Simplified, accurate method for antibiotic assay of clinical specimens. Applied Microbiol., 14: 170-177.
PubMedDirect Link - Mestorino, N., M.F. Landoni, M. Alt and J.O. Errecalde, 1993. The pharmacokinetics of thiamphenicol in lactating cows. Vet. Res. Commun., 17: 295-303.
CrossRefDirect Link - Abdennebi, E.H., N. Khales, R.J. Sawchuk and C.M. Stowe, 1994. Thiamphenicol pharmacokinetics in sheep. J. Vet. Pharmacol. Ther., 17: 12-16.
PubMedDirect Link - Harritove, A., L. Lashev and D. Pashov, 2002. Pharmacokinetics of thiamphenicol in pigs. J. Vet. Pharmacol. Ther., 25: 464-466.
PubMedDirect Link - McChenseney, E.W., R.F. Koss, J.M. Sherosky and W.H. Deitz, 1960. Metabolism of dextrosulphenidol in several animal species. J. Am. Pharm. Assoc., 49: 741-788.
Direct Link - Nakagawa, T., M. Masada and T. Uno, 1975. Gas chromatographic determination and gas chromatographic-mass spectrometric analysis of chloramphenicol, thiamphenicol and their metabolities. J. Chromatography, 111: 355-364.
PubMedDirect Link - Kaufman, C.F. and E.N. Bergman, 1978. Renal function studies in normal and toxemic pregnant sheep. Cornell Vet., 68: 124-137.
PubMedDirect Link - Cambiers, F., A. Gambini and E. Lodola, 1970. Diffusion of chloramphenicol and thiamphenicol in the bronchial secretions and in the lung tissue. Chemotherapy, 15: 356-365.
CrossRefDirect Link - Mengozzi, G., L. Intorre, S. Bertini, M. Giorgi, P.L. Secchiari and L. Soldani, 2002. A comperative kinetic study of thiamphenicol in pre-ruminant lambs and calves. Res. Vet., Sci., 73: 291-295.
CrossRefDirect Link