T. J. Feuerstein
Neurozentrum, Breisacherstrasse 64, D-79106 Freiburg, Germany
W. Sauermann
Datamap, Munnnger Strasse 5A, D-79111 Freiburg, Germany
ABSTRACT
There are semilogarithmic (lg-) concentration-response sigmoids with slopes exactly representing the opposite asymmetry of that encountered in the case of a receptor reserve (reserve: large curvature in the left part of the curve and narrow curvature in the right part; opposite: narrow curvature in the left part of the curve and large curvature in the right part). In addition, the binding Kds of agonists are smaller than their EC50 in such curves. Using experimental concentration-response data a non-linear fitting model of a receptor "antireserve" was developed which is the topic of the present paper. This model reflects the possibility of a subthreshold preactivation of a signaling system. Hypothetically, only after exceeding this threshold a receptor-mediated response takes place.
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How to cite this article
T. J. Feuerstein and W. Sauermann, 2005. What is the Opposite of a Receptor Reserve?. International Journal of Pharmacology, 1: 195-202.
DOI: 10.3923/ijp.2005.195.202
URL: https://scialert.net/abstract/?doi=ijp.2005.195.202
DOI: 10.3923/ijp.2005.195.202
URL: https://scialert.net/abstract/?doi=ijp.2005.195.202
REFERENCES
- Feuerstein, T.J. and N. Limberger, 1999. Mathematical analysis of the control of neurotransmitter release by presynaptic receptors as a supplement to experimental data. Naunyn Schmiedberg's Arch. Pharmacol., 359: 345-359.
CrossRefDirect Link - Sauermann, W. and T.J. Feuerstein, 1998. Some mathematical models for concentration-response relationships. Biometrical J., 40: 865-881.
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