Trends in Medical Research1819-35872151-6065Science International10.3923/tmr.2020.22.28Dennettia tripetala Extracts Up-regulate Haematopoiesis against Carbon Tetrachloride Toxicity]]>Oghogho OmageSylvia OmageKingsley 12020151Background and Objective: The use of Dennettia tripetala in ethnomedicine to manage pain, inflammation and fever have been attributed to its analgesic effects. In this study, we evaluated the effect of Dennettia tripetala extracts on hematopoiesis against carbon tetrachloride-induced toxicity. Materials and Methods: Thirty Wistar experimental rats were weighed and randomized into six groups of five rats each. The rats were treated as described below in strict accordance with the NIH guidelines for the care and use of laboratory animals. Results: Administration of aqueous extract of Dennettia tripetala and subsequently carbon tetrachloride resulted in significant (p<0.05) increases in white blood cell count, percentage monocytes, percentage granulocytes and decreases in percentage Lymphocytes. Administration of the ethanolic extract and subsequently carbon tetrachloride resulted in significant (p<0.05) increases in white blood cells, percentage monocytes and granulocytes. Administration of the 250 mg kg1 with carbon tetrachloride resulted in significant (p<0.05) increases in red blood cells and haemoglobin while the 1000 mg kg1 ethanolic Dennettia tripetala extract alone caused Hematocrit and mean corpuscular volume to increase and mean corpuscular hemoglobin concentration to decrease significantly. Conclusion:Dennettia tripetala extracts at low doses up-regulated hematopoiesis which possibly prevented the harmful effects of carbon tetrachloride.]]>Liu, K.X., Y. Kato, M. Yamazaki, O. Higuchi, T. Nakamura and Y. Sugiyama,199317651660Seifert, W.F., A. Bosma, A. Brouwer, H.F.J. Hendriks and P.J.M. Roholl et al.,199419193201Masuda, Y.,2006126885899Recknagel, R.O., E.A. Glende, Jr., J.A. Dolak and R.L. Waller,198943139154Rood, A.S., P.D. McGavran, J.W. Aanenson and J.E. Till,200121675696Singh, A., T.K. Bhat and O.P. Sharma,20112011Omage K., O.K. Orumwensodia, O.O. Osewenkhae and I.V. Bazuaye,2015Acalypha wilkesiana leaves.]]>14124133Iseghohi, S.O. and N.E.J. Orhue,2017Dennettia tripetala ameliorates liver and kidney damage caused by multiple exposures to carbon tetrachloride.]]>2017Ashafa, A.O.T., M.T. Yakubu, D.S. Grierson and A.J. Afolayan,2009Chrysocoma ciliata L. on some biochemical parameters of Wistar rats.]]>814251430Yakubu, M.T., M.A. Akanji and A.T. Oladiji,2007Fadogia agrestis stem.]]>33438Kingsley, O. and A.A. Marshall,2014Acalypha wilkesiana leaves.]]>2655665Iseghohi, S.,2015Dennettia tripetala (pepperfruit).]]>3104111Oyemitan, I.A., E.O. Iwalewa, M.A. Akanmu and T.A. Olugbade,2008Dennettia tripetala G.Baker (Annonaceae) in rodents.]]>5355362Iseghohi, S.O., N.E.J. Orhue, K. Omage,2017Dennettia tripetala ethanolic fruit extract prevents biochemical alterations in rats subsequently exposed to a single dose of carbon tetrachloride.]]>6816Anaga, A.O. and I.U. Asuzu,2009Dennetia tripetala in diabetic rats.]]>2009Sparg, S.G., M.E. Light and J. van Staden,200494219243Riehemann, K., B. Behnke and K. Schulze-Osthoff,1999Urtica dioica), an antirheumatic remedy, inhibit the proinflammatory transcription factor NF-κB.]]>4428994Anaga, A.O. and I.U. Asuzu,2011Dennettia tripetala in 3T3-L1 adipocytes.]]>8114Ikpi, D.E. and C.O. Nku,2008Dennettia tripetala fruit on haematological parameters in albino Wistar rats.]]>231317Anaga, A.O., S.V.O. Shoyinka and I.U. Asuzu,2006Dennettia tripetala. root extract.]]>44451461Anyaele, O.O. and A.A.S. Amusan,2003Dennettia tripetala on larvae of Aedes aegypti.]]>64953Omage, S.O., N.E. Orhue and K. Omage,2019in vitro antioxidant capacity, biochemical and histological effects of Dennettia tripetala fruits in healthy rats.]]>76575Jee, S.H., J.Y. Park, H.S. Kim, T.Y. Lee and J.M. Samet,200516210621069Cherfane, C.E., L. Gessel, D. Cirillo, M.B. Zimmerman and S. Polyak,20152117691775Shi, C. and E.G. Pamer,201111762774Osuagwu, G.G.E. and C.F. Eme,2013Dialium guineense, Vitex doniana and Dennettia tripetala leaves.]]>26981Omage, K., M.A. Azeke and S.O. Omage,2018Acalypha wilkesiana leaves in managing cardiovascular disease risk factors in rabbits exposed to salt-loaded diets.]]>2018Spinner, M.A., L.A. Sanchez, A.P. Hsu, P.A. Shaw and C.S. Zerbe et al.,2014123809821De Sousa, R.R.R., K.C.S. Queiroz, A.C.S. Souza, S.A. Gurgueira and A.C. Augusto et al.,200722439444Cushnie, T.P.T. and A.J. Lamb,200526343356Yamamoto, Y. and R.B. Gaynor,2001107135142