Trends in Medical Research1819-35872151-6065Science International10.3923/tmr.2017.26.31FagbohunO.F. O. Emma-OkonB. K. AgboolaF. A. KolawoleB. H. OnakpoyaO. OdewoleT.O. 12017121Background: Levels of Zn, Cu, Mg, vitamin E and vitamin C were measured in 65 Nigerian diabetic subjects with and without micro vascular complications and compared with controls, in order to ascertain their association with the disease and its complications. Methods: Fasting blood glucose, glycated hemoglobin, Zn, Cu, Mg, vitamin E and vitamin C were assayed according to standard procedures. Statistical analysis was carried out using SPSS version 17.0. Results: Mean values of Zn, Mg and vitamin E were significantly higher (p<0.05) in control groups than diabetic subjects. The Zn levels correlated negatively with fasting blood glucose (p = 0.000, R = -0.443) and glycated hemoglobin (p = 0.030, R = -0.269) while Mg and vitamin E correlated negatively with fasting blood glucose (p = 0.000. R = -0.405 and p = 0.000, R = -0.524, respectively). The Zn, Mg and vitamin E levels correlated positively with each other. Diabetic subjects with retinopathy and nephropathy had significantly lower levels of vitamin E than others. Conclusion: Alterations in trace elements and vitamin status were observed in Nigerian diabetes mellitus subjects. The pattern differs from previous studies in respect of Cu and vitamin C levels. The alterations appear to be more as a result of diabetes itself, rather than being involved in the progression of the disease.]]>IDF.,20152015Ceriello, A.,2000492729Baynes, J.W. and S.R. Thorpe,19994819Nozik-Grayck, E., H.B. Suliman and C.A. Piantadosi,20053724662471Feher, J., G. Csomos and A. Vereckei,1987Pages: 199Pages: 199Padayatty, S.J., A. Katz, Y. Wang, P. Eck and O. Kwon et al.,2003221835Onah, C.E., S.C. Meludu, C.E. Dioka, U.K. Amah, J.E. Okwara and C.U. Osuji,20131129134Wali, U., M.U. Jogana, A.L. Zarummai and Y. Saidu,201119130134Akhuemokhan, K.I., A. Eregie and O.A. Fasanmade,201012022Abe, A., S. Yamashita and A. Noma,198935552554Johnsen, O. and R. Eliasson,198710435440Rutkowski, P., S. Malgorzewicz, E. Slominska, M. Renke, W. Lysiak-Szydlowska, J. Swierczynski and B. Rutkowski,200616190193VanderJagt, D.J., P.J. Garry and W.C. Hunt,19863210041006ADA.,199922S1S114Walter, Jr. R.M., J.Y. Uriu-Hare, K.L. Olin, M.H. Oster, B.D. Anawalt, J.W. Critchfield and C.L. Keen,19911410501056Masood, N., G.H. Baloch, R.A. Ghori, I.A. Memon, M.A. Memon and S.A. Memon,200919483486Sinha, S. and S. Sen,201434220223Pai, L.H. and A.S. Prasad,19888889897Niewoehner, C.B., J.I. Ellan, M. Boosalis, A.S. Levine and J.E. Morley,1986816368Hayee, M.A., Q.D. Mohammad and A. Haque,2005316267Noto, R., R. Alicata, L. Sfogliano, S. Neri and M. Bifarella,1983208185Abou-Seif, M.A. and A.A. Youssef,2004346161170Thomas, B., S. Kumari, K. Ramitha and M.B.A. Kumari,2010144649Diwan, A.G., A.B. Pradhan, D. Lingojwar, K.K. Krishna, P. Singh and S.I. Almelkar,200626122123McNair, P., C. Christiansen, S. Madsbad, E. Lauritzen, O. Faber, C. Binder and I. Transbol,19782710751077Bursell, S.E., A.C. Clermont, L.P. Aiello, L.M. Aiello and D.K. Schlossman et al.,19992212451251Suksomboon, N., N. Poolsup and S. Sinprasert,2011365363Sinclair, A.J., P.B. Taylor, J. Lunec, A.J. Girling and A.H. Barnett,199411893898