Trends in Medical Research1819-35872151-6065Science International10.3923/tmr.2016.82.87IsmailNagwa Abdallah El DayemSoha M. Abd HamedMona AyoubDina F. HassanEman Mahmoud AssalHeba 22016112Controlling of inflammatory process associated with obesity is a big challenge. Both Monocyte Chemoattractant Protein-1 (MCP-1) and macrophage Migration Inhibitory Factor (MIF) may play a role in this process. Aim to evaluate serum MPC-1 and MIF levels in obese subjects and detect the effect of oral curcumin intake. The study included 60 obese subjects (30 children and 30 adults). The trial subjects received a 500 mg curcumin capsule with the main meal for 4 weeks. Controls received a placebo capsule for 4 weeks. A total of 60 normal weights enrolled as controls. The MIF and MCP-1 levels were measured on days 1 and 29 using commercially available ELISA kits. The mean serum level of MPC-1 and MIF were significantly higher in obese group than in controls. Curcumin intake resulted in statistically significant decrease in serum MPC-1 and serum MIF in children and adults. Our results showed that curcumin could help in lowering MIF and MPC-1 associated with obesity. It could help in prevention of obesity complications.]]>Anto, R.J., A. Mukhopadhyay, K. Denning and B.B. Aggarwal,200223143150Azza, M.A., S.H. Ragab, N.A. Ismail, M.A.M. Awad and M.E. Kandil,201114711Benigni, F., T. Atsumi, T. Calandra, C. Metz, B. Echtenacher, T. Peng and R. Bucala,200010612911300Black, R.E., C.G. Victora, S.P. Walker, Z.A. Bhutta and P. Christian et al.,2013382427451Bruun, J.M., A.S. Lihn, S.B. Pedersen and B. Richelsen,20059022822289Cheng, Y., A. Kozubek, L. Ohlsson, B. Sternby and R.D. Duan,200773725730Deurenberg, P., J.A. Weststrate and J.C. Seidell,199165105114Ezzat, W.M., S. Ragab, N.A. Ismail, Y.A. Elhosary, A.M.N.E. Abd ElBaky, H. Farouk and I.A. Rasheed,201210221227Flaster, H., J. Bernhagen, T. Calandra and R. Bucala,20072112671280Ismail, N.A., S. Ragab, A.N.E. Abd El Baky, M. Hamed and A.S.A. Ibrahim,20145887896Lan, H.Y.,2008109e79e83Lobstein, T. and R. Jackson-Leach,200613341Lue, H., R. Kleemann, T. Calandra, T. Roger and J. Bernhagen,20024449460Murao, K., H. Imachi, A. Momoi, Y. Sayo and H. Hosokawa et al.,19994542730Ng, M., T. Fleming, M. Robinson, B. Thomson and N. Graetz et al.,2014384766781Pan, J.H., G.K. Sukhova, J.T. Yang, B. Wang and T. Xie et al.,200410931493153Sartipy, P. and D.J. Loskutoff,200310072657270Sandur, S.K., H. Ichikawa, M.K. Pandey, A.B. Kunnumakkara, B. Sung, G. Sethi and B.B. Aggarwal,200743568580Deshmane, S.L., S. Kremlev, S. Amini and B.E. Sawaya,201029313326Yoshimura, T., E.A. Robinson, S. Tanaka, E. Appella, J. Kuratsu and E.J. Leonard,198916914491459Zernecke, A., J. Bernhagen and C. Weber,200811715941602Ghalli, I., N. Salah, F. Hussien, M. Erfan and M. El-Ruby et al.,20082008