Trends in Medical Research1819-35872151-6065Science International10.3923/tmr.2013.63.85H. pylori and its Eradication on Gastric Ghrelin Secretion]]>MohammedMohammed Amin OmarNesreen Moustafa 2201382Helicobacter pylori infection and its eradication may influence plasma levels and gastric production of some peptides, which can affect appetite. Ghrelin, an orexigenic hormone, is primarily produced in and secreted from oxyntic mucosa of the stomach. Ghrelin has been demonstrated to play a central role in appetite, food intake and energy homeostasis. As ghrelin production in human is exclusively gastric origin, it is conceivable and not surprising that any injury to the gastric mucosa will affect plasma ghrelin concentrations. To verify this hypothesis, a total of 135 adult consecutive individuals with normal body mass index including 84 H. pylori-infected and 51 H. pylori-negative subjects were included in a randomized controlled trial. Gastric ghrelin mRNA expression levels were measured in endoscopic biopsy specimens in both groups before and after H. pylori eradication. Also, plasma active n-octanoyl ghrelin and obestatin levels and ghrelin/obestatin ratio were measured in both groups before and after H. pylori eradication. The treatment group (44/84) received triple H. pylori eradication therapy for 7 days and followed up for 6 months. In contrast to obestatin, plasma and gastric ghrelin mRNA expression levels were significantly lower in H. pylori-infected subjects. H. pylori eradication significantly reversed these changes. The decrease in plasma ghrelin concentration in H. pylori-positive subjects was accompanied by depletion of ghrelin mRNA expression. These findings suggest that H. pylori induced chronic gastritis impair gastric ghrelin production and consequently the decrease in plasma ghrelin concentration.]]>Ariyasu, H., K. Takaya, T. Tagami, Y. Ogawa and K. Hosoda et al.,20018647534758Asakawa, A., A. Inui, T. Kaga, H. Yuzuriha and T. Nagata et al.,2001120337345Azuma, T., H. Suto, Y. Ito, A. Muramatsu and M. Ohtani et al.,2002Helicobacter pylori infection induces an increase in body mass index.]]>16240244Bartuzi, Z., E. Gawronska-Ukleja and B. Romanski,2000612031208Bellone, S., A. Rapa, D. Vivenza, A. Vercellotti and A. Petri et al.,200326RC911Brown, L.M.,200022283297Cummings, D.E., D.S. Weigle, R.S. Frayo, P.A. Breen, M.K. Ma, E.P. Dellinger and J.Q. Purnell,200234616231630Date, Y., M. Kojima, H. Hosoda, A. Sawaguchi and M.S. Mondal et al.,200014142554261De Boer, W.A., R.J. van Etten, R.W. Schade, M.E. Ouwehand, P.M. Schneeberger and G.N. Tytgat,1996Helicobacter pylori infection.]]>9117781782Del Giudice, G. and P. Michetti,2004Helicobacter pylori.]]>92328Dixon, M.F., R.M. Genta, J.H. Yardley and P. Correa,19962011611181Drossman, D.A.,200613013771390Gasbarrini, A., E. Carloni, G. Gasbarrini and S.A. Chisholm,2004Helicobacter pylori and extragastric diseases-other Helicobacters.]]>95766Gasbarrini, A., F. Franceschi and D.B. De Miquel,1999Helicobacter pylori in extradigestive diseases.]]>152933Gokcel, A., Y. Gumurdulu, F. Kayaselcuk, E. Serin, B. Ozer, A.K. Ozsahin and N. Guvener,2003148423426Goodwin, C.S., M.M. Mendall and T.C. Northfield,1997Helicobacter pylori infection.]]>349265269Hofman, P., B. Waidner, V. Hofman, S. Bereswill, P. Brest and M. Kist,2004Helicobacter pylori Infection.]]>91522Huda, M.S., B.H. Durham, S.P. Wong, D. Deepak and D. Kerrigan et al.,200832129135Isomoto, H., H. Ueno, Y. Nishi, C.Y. Wen, M. Nakazato and S. Kohno,2005Helicobacter pylori infection on ghrelin and various neuroendocrine hormones in plasma.]]>1116441648Jeffery, P.L., M.A. McGuckin and S.K. Linden,2011Helicobacter pylori: Focus on ghrelin and ghrelin o-acyltransferase.]]>1712491260Kim, D.Y. and J.Y. Baek,1999401419Kim, H.B., E.S. Lee, S.W. Oh, Y.H. Kim and D.E. Lee et al.,200829736745Kojima, M., H. Hosoda, Y. Date, M. Nakazato, H. Matsuo and K. Kangawa,1999402656660Konturek, P.C., T. Brzozowski, B. Walter, G. Burnat, T. Hess, E.G. Hahn and S.J. Konturek,2006536171181Lacquaniti, A., V. Donato, V. Chirico, A. Buemi and M. Buemi,201159193199Lee, E.S., Y.S. Yoon, C.Y. Park, H.S. Kim, T.H. Um, H.W. Baik and E.J. Jang,2010Helicobacter pylori increases ghrelin mRNA expression in the gastric Mucosa.]]>25265271Locatelli, V., E. Bresciani, I. Bulgarelli, D. Rapetti and A. Torsello et al.,200528843848Mackey, K. and P. Chomczynski,199687278Masuda, Y., T. Tanaka, N. Inomata, N. Ohnuma and S. Tanaka et al.,2000276905908Nakazato, M., N. Murakami, Y. Date, M. Kojima, H. Matsuo, K. Kangawa and S. Matsukura,2001409194198Nweneka, C.V. and A.M. Prentice,2011Helicobacter pylori infection and circulating ghrelin levels: A systematic review.]]>2011Nwokolo, C.U., D.A. Freshwater, P. O'Hare and H.S. Randeva,2003Helicobacter pylori.]]>52637640Osawa, H., M. Nakazato, Y. Date, H. Kita and H. Ohnishi et al.,2005Helicobacter pylori.]]>901016Osawa, H.,2008Helicobacter pylori infection.]]>1463276333Patrono, C. and B.A. Peskar,1987Shiotani, A., T. Miyanishi, N. Uedo and H. Iishi,200510373378Schreiber, S., M. Konradt, C. Groll, P. Scheid and G. Hanauer et al.,2004Helicobacter pylori in the gastric mucus.]]>10150245029Slomiany, B.L. and A. Slomiany,2011Helicobacter pylori-induced S-nitrosylation-dependent Akt inactivation exerts modulatory influence on gastric mucin synthesis.]]>198997Slomiany, B.L. and A. Slomiany,2011Helicobacter pylori induces disturbances in gastric Mucosal Akt activation through inducible nitric oxide Synthase-dependent S-nitrosylation: Effect of Ghrelin.]]>2011Stemmermann, G.N.,199474556564Stevens, A. and R.J. Francis,19961996pp: 291-308pp: 291-308Tschop, M., D.L. Smiley and M.L. Heiman,2000407908913Uemura, N., S. Okamoto, S. Yamamoto, N. Matsumura and S. Yamaguchi et al.,2001345784789Weigle, D.S., D.E. Cummings, P.D. Newby, P.A. Breen and R.S. Frayo et al.,20038815771586Yanai, A., S. Maeda, W. Shibata, Y. Hikiba and K. Sakamoto et al.,2008Helicobacter pylori-induced chronic gastritis in Mongolian gerbils.]]>76781787