Trends in Medical Research1819-35872151-6065Science International10.3923/tmr.2006.49.54GodeiroKatyanne D.AnteckaEmilia de A. FrotaAna CarolinaOdashiroAlexandre NakaoMaloneyShawn BurnierMiguel N.1200611The purpose of this study was to characterize the expression of PSMA and evaluate its possible association with clinicopathological features in Uveal Melanoma (UM). Fifty-five UM specimens were subjected to immunohistochemistry with anti-PSMA monoclonal antibody. Prostatic hyperplasia was used as a positive control. The endothelial cells of the tumor-associated neovasculature and UM cells in all of the 55 UM cases demonstrated negative staining to PSMA. Since there is no expression of PSMA in UM, this protein does not represent a new target for antineovasculature-based therapy for UM patients. Therefore, the search for new treatments, especially those focusing on hematogenous metastatic spread, is necessary.]]>Arora, N., A. Naveen, M. Rizwan, Z. Tong and J. Cai et al.,199959183188Brown, L.F., A.J. Guidi, K. Tognazzi and H.F. Dvorak,199846569575Carter, R.E., A.R. Feldman and J.T. Coyle,199693749753Chang, S.S., E. Reuter Victor, W.D.W. Heston and B.G. Paul,200157801805Chang, S.S., P.B. Gaudin, V.E. Reuter, D.S. O'Keefe, D.J. Bacich and W.D. Heston,19993313320Chang, S.S., V.E. Reuter, W.D.W. Heston, N.H. Bander, L.S. Grauer and P.B. Gaudin,19995931923198Chang, S.S., D.S. O'Keefe, D.J. Bacich and V.E. Reuter,1999526742681De La Cruz, P.O. Jr., C.S. Specht, I.W. McLean,199065112115Diener-West, M., B.S. Hawkins, J.A. Markowitz and A.P. Schachat,1992110245250Egan, K.M., J.M. Seddon, R.J. Glynn, E.S. Gragoudas and D.M. Albert,198832239251Folberg, R.,199711227238Folkman, J.,19908246Folkman, J.,199512730Folkman, J. and R. Cotran,197616207248Gasparini, G., P.C. Brooks, E. Biganzoli, P.B. Vermeulen and E. Bonoldi,1998426252634Heston, W.D.,199749104112Horoszewicz, J.S., E. Kawinski and G.P. Murphy,19877927935Israeli, R.S., C. Thomas Powell, W.R. Fair and W.D.W. Heston,199353227230Kahn, D., R.D. Williams, M.J. Manyak, M.K. Haseman and D.W. Seldin et al.,199815920412047Liu, H., P. Moy, S. Kim, Y. Xia and A. Rajasekaran et al.,19975736293634Lopes, A.D., Wendy L. Davis, Maurice J. Rosenstraus, Albert J. Uveges and S.C. Gilman,19905064236429McLean, I.W., W.D. Foster, L.E. Zimmerman and J.W. Gamel,198396502509McLean, M.J., W.D. Foster and L.E. Zimmerman,1977954858Melia, B.M., D.H. Abramson, D.M. Albert, H.C. Boldt and J.D. Earle et al.,2001108348366Milowsky, M.I., Nanus DM, L. Kostakoglu, S. Vallabhajosula, S.J. Goldsmith and N.H. Bander20042225222531Nag, S., J.M. Quivey , J.D. Earle, D. Followill and J. Fontanesi et al.,200356544555Nanus, D.M. M.I. Milowsky, L. Kostakoglu and P.M.S. Jones et al.,2003170S8488O'Reilly, M.S., L. Holmgren, Y. Shing, C. Chen and R.A. Rosenthal et al.,199479315328Parkin, D.M., F. Bray, J. Ferlay and P. Pisani,200194153156Petronis, J.D., F. Regan and K.E. Lin,199823672677Pinto, J.T., B.P. Suffoletto, T.M. Berzin, C.H. Qiao and S. Lin et al.,1996214451451Saleh, M., S.A. Stacker and A.F. Wilks,1996in vivo by expression of antisense vascular endothelial growth factor sequence.]]>56393401Silver, D.A., I. Pellicer, W.R. Fair, W.D. Heston and C.C. Cardo,199738185Skobe, M., P. Rockwell, N. Goldstein, S. Vosseler and Norbert, E. Fusenig,1997312221227Wang, G., Z. cDong, G. Xu, Z. Yang and C. Shou et al.,1998124615620