Trends in Bioinformatics1994-79412077-2254Asian Network for Scientific Information10.3923/tb.2018.56.63BasumataryPanchamita DasManas BarmanPranjan ChoudhuryManisha 22018112Background and Objective: Extracts from Colocasia esculenta plant have been found to possess anti-inflammatory properties. 2, 3-Dimethylmaleic anhydride (3, 4-Dimethyl-2, 5-furandione) is a recent root stock extract of Colocasia esculenta. This study aimed to look for the possible anti-inflammatory activity of the 2, 3-Dimethylmaleic anhydride by docking study with the target protein, COX-2.Materials and Methods: Crystal structure of COX-2 was retrieved from RCSB protein data bank. The structure of 2, 3-Dimethylmaleic anhydride was retrieved from PubChem compound database in NCBI. Docking study was performed with the help of AutoDock 4.2.6. Results: Docking study showed that 2, 3-Dimethylmaleic anhydride fits into the cyclooxygenase active site of COX-2 with favourable binding energy. Conclusion: NSAIDs best known for their anti-inflammatory properties act by blocking COX enzymes suggest the compound 2, 3-Dimethylmaleic anhydride may possess anti-inflammatory potential bearing a role in alleviating the signs and symptoms of inflammation.]]>Smith, W.L., Y. Urade and P.J. Jakobsson,201111158215865Kurumbail, R.G., A.M. Stevens, J.K. Gierse, J.J. McDonald and R.A. Stegeman et al.,19971997Smith, W.L., D.L. DeWitt and R.M. Garavito,200069145182Harirforoosh, S., W. Asghar and F. Jamali,201316821847Chandrasekharan, N.V., H. Dai, K.L.T. Roos, N.K. Evanson, J. Tomsik, T.S. Elton and D.L. Simmons,2002991392613931O'Banion, M.K.,1999134582Abdulla, A., N. Adams, M. Bone, A.M. Elliott and J. Gaffin et al.,201342i157Ong, C.K.S., P. Lirk, C.H. Tan and R.A. Seymour,200751934Brennan, M.,198413110121013Prajapati, R., M. Kalariya, R. Umbarkar, S. Parmar and N. Sheth,2011Colocasia esculenta: A potent indigenous plant.]]>19096Agyare, C., Y.D. Boakye, J.A. Apenteng, S.O. Dapaah, T. Appiah and and A. Adow,2016Anchomanes difformis (Bl.) Engl. and Colocasia esculenta (L.) Schott.]]>2016Rajashekar, Y., N. Tonsing, T. Shantibala and J.R. Manjunath,2016Colocasia esculenta var. esculenta (L.) Schott.]]>2016Kurumbail, R.G., A.M. Stevens, J.K. Gierse, J.J. McDonald and R.A. Stegenman et al.,1996384644648Morris, G.M., R. Huey, W. Lindstrom, M.F. Sanner, R.K. Belew, D.S. Goodsell and A.J. Olson,20093027852791Kim, S., P.A. Thiessen, E.E. Bolton, J. Chen and G. Fu et al.,201544D1202D1213O'Boyle, N.M., M. Banck, C.A. James, C. Morley, T. Vandermeersch and G.R. Hutchison,20112011Wallace, A.C., R.A. Laskowski and J.M. Thornton,19958127134Garavito, R.M. and D.L. DeWitt,19991441278287Blobaum, A.L. and L.J. Marnett,20075014251441Zarghi, A. and S. Arfaei,201110655683Vecchio, A.J., B.J. Orlando, R. Nandagiri and M.G. Malkowski,20122872461924630Lucido, M.J., B.J. Orlando, A.J. Vecchio and M.G. Malkowski,20165512261238Lecomte, M., O. Laneuville, C. Ji, D.L. DeWitt and W.L. Smith,19942691320713215Shimokawa, T. and W.L. Smith,19922671238712392Blobaum, A.L. and L.J. Marnett,20075014251441Rowlinson, S.W., J.R. Kiefer, J. Prusakiewicz, J.L. Pawlitz and K.R. Kozak et al.,20032784576345769Clark, K., R. Kulathila, J. Koehn, S. Rieffel and A. Strauss et al.,20042004pp: 2226Gautam, R., A. Srivastava, S.M. Jachak and A. Saklani,2010Dysophylla stellata Benth.]]>814549Gautam, R., S.M. Jachak, V. Kumar and C.G. Mohan,20112116121616Lin, J.K. and S.Y. Lin-Shiau,2001255966Miladiyah, I., J. Jumina, S.M. Haryana and M. Mustofa,2017In silico molecular docking of xanthone derivatives as cyclooxygenase-2 inhibitor agents.]]>998104Barone, M., G. Pannuzzo, A. Santagati, A. Catalfo, G. De Guidi and V. Cardile,20141961066122Luong, C., A. Miller, J. Barnett, J. Chow, C. Ramesha and M.F. Browner,19963927933