Trends in Bioinformatics1994-79412077-2254Asian Network for Scientific Information10.3923/tb.2018.33.43Cryptosporidium parvum]]>Aiman BarudinMohd Lokman Md IsaMuhammad Mat YusofAfzan 12018111Background and Objective: Studies on signal peptides remain little and lacking to Cryptosporidium. This study represents the first attempt to investigate selected putative protein sequences of Cryptosporidium parvum in its established genome database for signal peptide. Methodology: Prediction analysis of protein sequences and identification of signal peptides on this parasite were analysed by SignalP 4.1 server. A total of 100 protein sequences were randomly selected and analysed, of which 6 (6%) corresponded to be predicted as signal peptide sequences. Results: Based on the comparison of sequences with database protein sequences in GenBank NCBI, almost all protein sequences were highly conserved with other protein sequences from different species of Cryptosporidium. Considering the secretory proteins in Cryptosporidium, several virulence protein sequences of this parasite may also show presence of N-terminal signal peptide or not. Conclusion: Hence, further studies need to be carried out for identification of N-terminal signal peptide function in Cryptosporidium for facilitating its virulence and pathogenesis pathway.]]>Laurent, F. and S. Lacroix-Lamande,2017Cryptosporidium.]]>47711721Checkley, W., A.C. White, D. Jaganath, M.J. Arrowood and R.M. Chalmers et al.,2015Cryptosporidium.]]>158594Ying, X., X. Chen, Y. Wang, W. Fang and D. Luo,2009Brugia malayi and the evolution of secreted proteins in parasites.]]>10413211326Crowe, J., F.E. Lumb, M.M. Harnett and W. Harnett,20172017Marcilla, A., M. Trelis, A. Cortes, J. Sotillo and F. Cantalapiedra et al.,20122012Hewitson, J.P., J.R. Grainger and R.M. Maizels,2009167111Coakley, G., A.H. Buck and R.M. Maizels,20162083340Jimenez, J.C., J. Fontaine, C. Creusy, L. Fleurisse, J.M. Grzych, M. Capron and E. Dei-Cas,2014Giardia excretory/secretory proteins in Giardia intestinalis-infected BALB/c mice.]]>11327092718Gonzalez-Paez, G.E., F. Alba-Hurtado, C.G. Garcia-Tovar and R. Arguello-Garcia,2014Toxocara canis second-stage larvae: Zymography and modeling insights.]]>2014Ganga, G., J.P. Varshney and R.C. Patra,2007Fasciola gigantic.]]>215152Gomez, S., L. Adalid-Peralta, H. Palafox-Fonseca, V.A. Cantu-Robles and X. Soberon et al.,2015Taenia solium reveals their Abundance of Antigenic Regions (AAR).]]>2015Montaner, S., A. Galiano, M. Trelis, L. Martin-Jaular, H.A. del Portillo, D. Bernal and A. Marcilla,20142014Liao, Q., X. Yuan, H. Xiao, C. Liu, Z. Lv, Y. Zhao and Z. Wu,2011Schistosoma japonicum excretory/secretory proteins and their interactions with host immune system.]]>2011Klee, E.W. and L.B. Ellis,20052005Klee, E.W. and C.P. Sosa,200712234240Petersen, T.N., S. Brunak, G. von Heijne and H. Nielsen,20118785786Abrahamsen, M.S., T.J. Templeton, S. Enomoto, J.E. Abrahante and G. Zhu et al.,2004Cryptosporidium parvum.]]>304441445Johnson, M., I. Zaretskaya, Y. Raytselis, Y. Merezhuk, S. McGinnis and T.L. Madden,200836W5W9Madden, T.,20132013Pearson, W.R.,2013423.1.13.1.8Coletta, A., J.W. Pinney, D.Y.W. Solis, J. Marsh, S.R. Pettifer and T.K. Attwood,20102010Nielsen, H.,20172017pp: 59-73pp: 59-73Mousavi, P., Z. Mostafavi-Pour, M.H. Morowvat, N. Nezafat, M. Zamani, A. Berenjian and Y. Ghasemi,2017In silico analysis of several signal peptides for the excretory production of reteplase in Escherichia coli.]]>14326335Wang, T., J. Li, Y. Yang and T. Zhao,2016Pseudomonas syringae pv. tabaci yuexi-1 strain.]]>2292100Kumari, S. and A.K. Chaurasia,2016In silico analysis and experimental validation of lipoprotein and novel Tat signal peptides processing in Anabaena sp. PCC7120.]]>54837846Massahi, A. and P. Calik,2015In-silico determination of Pichia pastoris signal peptides for extracellular recombinant protein production.]]>364179188Massahi, A. and P. Calik,2016Pichia pastoris: From in-silico analysis to fermentation.]]>4082233Sun, P.N., X.L. Zhou and Z.X. Wang,2009Neurospora crassa phyA gene.]]>2910981101Huang, J.L., J.Z. Wu, C.G. Xiao, C.J. Li and G.X. Wang,2007Ralstonia solanacearum GMI1000.]]>2914091416Wu, H.Z., C.Y. Li, Y.Y. Zhu and Y.F. Bi,2006Caenorthaditis elegans ws123.]]>28470478Yang, J., C.Y. Li, Y.Y. Wang, Y.Y. Zhu and J.B. Li et al.,2006Saccharomyces cerevisiae.]]>5221227Pearson, M.S., D.P. McManus, D.J. Smyth, F.A. Lewis and A. Loukas,2005In vitro and in silico analysis of signal peptides from the human blood fluke, Schistosoma mansoni.]]>45201211Fan, C.M., C.Y. Li, M.F. Zhao and Y.Q. He,2005Agrobacterium tumefaciens C58.]]>45561566Choo, K.H., T.W. Tan and S. Ranganathan,200910(Suppl. 15)S2S2Bendtsen, J.D., L.J. Jensen, N. Blom, G. von Heijne and S. Brunak,200417349356Leversen, N.A., G.A. de Souza, H. Malen, S. Prasad, I. Jonassen and H.G. Wiker,200915523752383Karkowska‐Kuleta, J. and A. Kozik,201429270283Bouzid, M., P.R. Hunter, R.M. Chalmers and K.M. Tyler,2013Cryptosporidium pathogenicity and virulence.]]>26115134Sturbaum, G.D., B.H. Jost and C.R. Sterling,2003Cryptosporidium parvum surface protein encoding genes differentiate genotype I from genotype II isolates.]]>1288790O’Hara, S.P., J.R. Yu and J.J.C. Lin,2004Cryptosporidium parvum antigen, CP2, preferentially associates with membranous structures.]]>92317327Zhang, Z. and W.J. Henzel,20041328192824