Trends in Bioinformatics1994-79412077-2254Asian Network for Scientific Information10.3923/tb.2016.14.22Tachypleus tridentatus as a Stable Scaffold in Antifungal Peptide Design]]>SenthilkumarB. RajasekaranR. 1201691Background and Objective: Global increase in microbial infections has steered the production and improvement of antimicrobial and antifungal peptide drugs in pharmaceutical firm. In this study, structural stability of the antifungal peptide tachystatin B1 (2DCV) and B2 (2DCW) of Tachypleus tridentatus was computationally investigated. Materials and Methods: Static structure analysis showed high number of intra-molecular interactions in tachystatin B2 than B1 comparatively. Further, conformational sampling studies revealed tachystatin B2 to be structurally stable, substantiated by various structural events like root mean square deviation, ramachandran plot, radius of gyration, ovality and lipophilicity. Results: Moreover, the statistically validated contours of surface area, polar surface area, non polar surface area, hydrogen bond distribution and intra distance of disulfide bridges also supported the priority of tachystatin B2 with respect to stability. Conclusion: In this study, it is proposed that tachystatin B2 could be an efficient template for scaffolding antifungal peptide drugs.]]>Sievert, D.M., P. Ricks, J.R. Edwards, A. Schneider and J. Patel et al.,201334114Dignani, M.C.,20142014Li, Y., Q. Xiang, Q. Zhang, Y. Huang and Z. Su,201237207215Fujitani, N., S.I. Kawabata, T. Osaki, Y. Kumaki, M. Demura, K. Nitta and K. Kawano,20022772365123657Osaki, T., M. Omotezako, R. Nagayama, M. Hirata and S. Iwanaga et al.,19992742617226178Fujitani, N., T. Kouno, T. Nakahara, K. Takaya and T. Osaki et al.,200713269279Berman, H.M., J. Westbrook, Z. Feng, G. Gilliland and T.N. Bhat et al.,200028235242Van Der Spoel, D., E. Lindahl, B. Hess, G. Groenhof, A.E. Mark and H.J.C. Berendsen,20052617011718Kahn, K. and T.C. Bruice,200223977996Tina, K.G., R. Bhadra and N. Srinivasan,200735W473W476Pace, C.N., S. Trevino, E. Prabhakaran and J.M. Scholtz,200435912251235Seeliger, D. and B.L. de Groot,20093011601166Seeliger, D. and B.L. de Groot,201098428a428aPedretti, A., L. Villa and G. Vistoli,200418167173Humphrey, W., A. Dalke and K. Schulten,1996143338Colgrave, M.L. and D.J. Craik,20044359655975Senthilkumar, B., P. Kumar and R. Rajasekaran,2016In-silico template selection of in-vitro evolved kalata B1 of Oldenlandia affinis for scaffolding peptide-based drug design.]]>1176673Sreevishnupriya, K. and R. Rajasekaran,20138382389Unsworth, L.D., J. van der Oost and S. Koutsopoulos,200727440444056Kempner, E.S.,1993326410Carlsen, M., P. Koehl and P. Rogen,20142014Carrascoza, F., S. Zaric and R. Silaghi-Dumitrescu,201450125133Korn, A.P. and D.R. Rose,19947961967Lakshmi, B., C. Ramakrishnan, G. Archunan, R. Sowdhamini and N. Srinivasan,201463119125Dahl, D.B., Z. Bohannan, Q. Mo, M. Vannucci and J. Tsai,2008378749758Lobanov, M.Y., N.S. Bogatyreva and O.V. Galzitskaya,200842701706Adejoro, I.A., E. Akintemi, O.O. Adeboye and C. Ibeji,20147117128Hubbard, R.E. and M.K. Haider,20102010Vogt, G. and P. Argos,19972S40S46Durrant, J.D. and J.A. McCammon,20113159Stenberg, P., K. Luthman and P. Artursson,199916205212Gaillard, P., P.A. Carrupt, B. Testa and A. Boudon,199488396Chuang, C.C., C.Y. Chen, J.M. Yang, P.C. Lyu and J.K. Hwang,20035315Bulaj, G.,2005238792