Trends in Applied Sciences Research1819-35792151-7908Science International10.3923/tasr.2019.243.253SinghZorawar KhangotraPriya 42019144Telomeres present at ends of chromosomes are crucial in maintaining chromosomal integrity and genomic stability. In this review, variation in telomeric length was presented as potential biomarker in diagnosing lung, liver, gastric and pancreatic cancer types by going through available reports. A significant telomere shortening has been found to be associated with Non-small cell lung cancer (NSCLC) cases as compared to control patients (p = 0.027). A positive association between telomere length and survival outcome has been reported in case of squamous cell carcinomas in early stage NSCLC patients. Many studies reported the association of several single nucleotide polymorphisms and liver cirrhosis that may in turn become the main risk factor for liver cancer. Moreover, telomere shortening has been presented as a genetic risk factor for liver cirrhosis. Gastric cancer risk has been found to elevate with Helicobacter pylori L. infections which may involve telomere shortening mediated by over production of reactive oxygen species. Leucocyte telomere length and TERT gene variants were found to be associated with pancreatic cancer risk, but some studies found no associations between genetically predicted short telomeres and pancreatic ductal adenocarcinoma risk. Human telomerase reverse transcriptase plays an important role in telomere lengthening and has been found to be involved in different cancer propagatory mechanism. A wide group of studies revealed alteration in telomere length to be an accurate cancer biomarker though further associative studies are recommended.]]>Singh, Z. and P. Chadha,20162016Singh, Z.,20143511Singh, Z.,2018518Singh, Z. and R. Singh,2017410411044Augustine, T.A., M. Baig, A. Sood, T. Budagov and G. Atzmon et al.,2015112313318Augustine, T., R. Maitra and S. Goel,20178550558Biegler, K.A., A.K. Anderson, L.B. 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