Trends in Applied Sciences Research1819-35792151-7908Science International10.3923/tasr.2012.596.619TiwleRakesh Ajazuddin GiriTapan Kumar TripathiDulal Krishna JainVishal AlexanderAmit 8201278The combinatorial chemistry and high throughput screening increases the solubility
of poorly water soluble compounds. The most challenging task in development
of a formulation is the solubility of drug, availability at the site of action
and stability of drug. Aqueous solubility of any therapeutically active substance
is a key property as it governs dissolution, absorption and thus the in vivo
efficacy. Among all newly discovered chemical entities about 40% drugs are lipophilic
and these drugs are rejected by the pharmaceutical industry and will never benefit
a patient because of its poor bioavailability due to low water solubility and/or
cell membrane permeability. Drug efficacy can be severely limited by poor aqueous
solubility and some drugs also show side effects due to their poor solubility.
Therefore, drug release profiles are exhibited by such formulations for poorly
soluble drugs to improve the solubility of such poorly soluble drugs. Any drug
to be absorbed must be present in the form of an aqueous solution at the site
of absorption. Water is the solvent of choice for liquid pharmaceutical formulations.
Most of drugs which are weakly acidic and basic show poor aqueous solubility
hence various methods like, salt formation, co-solvency, micronization, addition
of agent, solid dispersion, complexation etc., are some of the vital approaches
routinely employed to enhance the solubility of poorly soluble drugs. This article
reviews various methods used for improving the solubility of hydrophobic drugs
and improve the drug release profiles which are exhibited by such formulations
for poorly soluble drugs.]]>Lima, A.A.N., Jose, L.S. Sobrinho, Roberto A.C. Correa Jr. and J. Pedro, Rolim Neto,200827789797Aejaz, A., K. Azmail, S. Sanaullah and A.A. Mohsin,2010in vitro evaluation.]]>2111115Ain, S., Q. Ain and S. Parveen,2009284104Ajazuddin and S. Saraf,201081110Ajazuddin and S. Saraf,20112011Ajazuddin and S. Saraf,20102318322Akers, M.J.,20029122832300Amit, A., R. Chaurasia, J. Khan, Swarna, S. Sahu and S. Patel,20112206209Alexander, A., Ajazuddin, D.K. Tripathi, T. Verma, Swarna, J. Maurya and S. Patel,20112434445Alexander, Amit Sharad Sharma, Ajazuddin, Khan Mohammed Junaid and Swarna,2011211551161Alexander, A., Ajazuddin, D.K. Tripathi, V. Tekeshwar, P. Sandip, D. Harsh and Swarna,2011415191525Al-Haj, N. and A. Rasedee,200959093Worthen, D.B.,2006Pages: 544Pages: 544Badawi, A.A., M.A. El-Nabarawi, D.A. El-Setouhy and S.A. Alsammit,20111144159Saritha, A. and N. Shastri,20102308311Amarji, B., Ajazuddin, D. Raghuwanshi, S.P. Vyas and P. 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