Trends in Applied Sciences Research1819-35792151-7908Science International10.3923/tasr.2011.1214.1221AliA. KhorshidF. Abu-arakiH. OsmanA.M. 102011610This study aimed to elaborate an experimental model of pulmonary carcinogenesis in healthy mice and to ascertain the preventive efficacy of PMF when administered against experimental lung carcinogenesis. Male Swiss Albino mice lineage was carried through an intra-peritoneal injection of the Benzo[a] pyrene diluted in corn oil, a polycyclic aromatic hydrocarbon is widely known by its power of tumoral lung induction. Four experimental groups had been used with 20 animals in each: The first is control group (without infection or treatment); the second is carcinogenic group without treatment, the third is treated carcinogenic group, the fourth is positive control group received only treatment, submitted to euthanasia 08, 16, 24 weeks after the experimental procedure. After 08 weeks, the presence of diffuse inflammatory alterations was observed in carcinogenic- non treated group with thickness of the alveolar wall after the inflammation, however, at analysis of the pulmonary tissue of the treated carcinogenic group it had been observed hyperplasic alterations (BALT hyperplasia) but in positive control group thickness of the alveolar wall was noticed. With more time, after 16, 24 weeks administration of PMF histopathological changes became lesser in the treated carcinogenic group as compared to animals treated with the B[a]P only. In conclusion, the main secondary alterations in the intra-pulmonary instillation of B[a]P of mice were: cellular proliferation, inflammatory alterations of several degrees. PMF treatment has a slightly protective effect to lung tissue along short time but with more time it improved the structure of the lung in carcinogenic treated group.]]>Araya, M., M. Olivares, F. Pizarro, M.A. Mendez, M. Gonzalez and R. Uauy,200513523672371Castro, M.E., R. Molina, W. Diaz, S.E. Pichuantes and C.C. Vasquez,2008Aeromonas caviae ST exhibits NADH-dependent tellurite reductase activity.]]>3759194Coufal, M., M.M. Maxwell, D.E. Russel, A.M. Amore and S.M. Altmann et al.,200712351360Cragg, G.M. and D.J. Newmann,20009115Coates, R.J., N.S. Weiss, J.R. Daling, R.L. Rettmer and G.R. Warnick,19894943534356Drury, R.A. and E.A. Wallington,19804th Edn.,El-Banhawy, M. and M. El-Gansory,19891st Edn.,El-Shahawy, A., N.M. Elsawi, W.S. Baker, F. Khorshid and N.S. Geweely,20101119Ferlay, J., F. Bray, P. Pisani and D.M. Parkin,20002000Galan. P., S. Briancon, A. Favier and S. Bertrais and P. Preziosi et al.,200594125132Gupta, S., K. Hastak, N. Ahmad, J.S. Lewin and H. Mukhtar,200181035010355Khorshid, F.A.,20084443451Khorshid, F.A.,20094815Khorshid, F.A., S.A. Rahimaldeen and J.S. Al-Amri,20115150155Khorsid, F.A. and S.S. Mushref,2006In vitro anticancer agent I-tissue culture study of human lung cancer cells A549 II-tissue culture study of mice leukemia cells L1210.]]>2330344Khorshid, F.A.,20042512111233Khorshid, F.A., A.A.M. Osman and E. Abdul-Sattar,2009810911098Khorshid, F.A., S.S. Mosherf and N.M. Tawfiq,2005in vitro, I-tissue culture study of human lung cancer cells A549.]]>12319Landau, J.M., Z.Y. Wang, G.Y. Yang, W. Ding and C.S. Yang,199819501507Lee, K.H.,199919569596Liao, J., G.Y. Yang, E.S. Park, X. Meng and Y. Sun et al.,2004484453Mahboub, F.A. and F.A. Khorshid,2010in vitro) study.]]>67888Moshref, S.S., F.A. Khorshid and Y. Jamal,2006in vitro) II-in vivo study on mice.]]>13319Moshref, S.S.,2007In vivo clinical and histopathological study.]]>148599Nioya, H.K., D.A. Ofusori, S.C. Nwangwn, O.F. Amegor, A.J. Akinyeye and T.A. Abayomi,20097160165Ahmed, G.A.R., F.A.R. Khorshid and T.A. Kumosani,20092396408Sandstead, H.H. and A.U. William,20072007pp: 925-947pp: 925-947Shimizu, M., A. Deguchi, J.T. Lim, H. Moriwaki, L. Kopelovich and I.B. Weinstein,20051127352746Verschraegen, C.F., B.E. Gilbert, E. Loyer, A. Huaringa, G. Walsh, R.A. Newman, V. Knight,20041023192326Vuorela, P., M, Leinonen, P. Saikku, P. Tammela, J.P. Rauha, T. Wennberg and H. Vuorela,20041113751389Widodo, N., K. Kaur, B.G. Shrestha, Y. Takagi, T. Ishii, R. Wadhwa and S.C. Kaul,20071322982306Wong, P.F. and S. Abu Baker,200822242247Zhang, Z., Q. Liu, L.E. Lantry, Y. Wang and G.J. Kelloff et al.,2000p53 mutation accelerates pulmonary tumorigenesis: p53-independent efficacy of chemopreventive agents green tea or dexamethasone/myo-inositol and chemotherapeutic agents taxol or adriamycin.]]>60901907