Research Journal of Veterinary Sciences1819-19082151-786xScience International10.3923/rjvs.2018.1.10Pentaclethra macrophylla on Rabbits]]>CedricYamssi Khan PayneVincent Anangmo Christelle NadiaNoumedem KodjioNorbert KollinsEtung MegwiLeonelle KuiateJules-Roger MbidaMpoame 12018111Background and Objective: Coccidiosis caused by protozoans of the Eimeria genus is a serious problem for the health of rabbits (Oryctolagus cuniculus) and their production. This study was therefore carried out in order to scientifically validate the use of Pentaclethra macrophylla in fighting against Coccidiosis. Materials and Methods: A total of 48 domestic rabbits (60 days old and about 1.5-2 kg b.wt.) and free from coccidia infection were used. All groups except group 6 were infected with 1000 sporulated Eimeria intestinalis oocysts. Faecal samples were collected and examined starting on day 1 post-inoculation until Day 9 post-inoculation, during which oocysts appeared in faeces. For quantitative analysis or determination of the number of oocysts per gram (OPG) of faeces, the Mc Master technique was used. Serum was used for determination of biochemical parameters related to oxidative stress such as superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), malondialdehyde (MDA), nitric oxide (NO) and glutathione using standardized diagnostic kits and a spectrophotometer. Results: The highest oocyst count reduction rate was 95% in the group which received the standard anti-coccidial drug. Among the groups that received the plant extract, the highest oocyst reduction rate was 69.41% at a dose of 500 mg kg1 and reduced in a dose-dependent manner from 58.92% (250 mg kg1) and then 55.01% (125 mg kg1). The result showed a significant decrease in tissues and serum catalase and peroxidase and a significant increase in NO, MDA and GLU levels in negative control animals. Treatment resulted in a significant normalization of the levels of the above markers when compared with the neutral control group. Conclusion: Our findings, therefore scientifically validate the use of P. macrophylla in fighting against Coccidiosis.]]>Coudert, P., D. Licois and V. Zonnekeyn,20008215218Al-Mathal, E.M.,2008Oryctolagus cuniculus domesticus L. in Saudi Arabia.]]>33035Metwaly, M.S., M.A. Dkhil, M.M. Gewik, A.O. Al-Ghamdy and S. Al-Quraishy,2013Eimeria coecicola.]]>11231093114Van Praag, E.,20132013Al-Mathal, E.M.,2010Commiphora molmol against hepatic coccidiosis (Eimeria stiedae) in the domestic rabbit.]]>810721080Vancraeynest, D., M. de Gussem, M. Marien and L. Maertens,2008Eimeria challenged rabbits.]]>2008pp: 11031106Chapman, H.D.,200988813815Dalloul, R.A. and H.S. Lillehoj,20054918Mortensen, L.L., L.H. Williamson, T.H. Terrill, R.A. Kircher, M. Larsen and R.M. Kaplan,2003223495500Youn, H.J. and J.W. Noh,2001Eimeria tenella.]]>96257263Hamad, K.K., Z. Iqbal, R.Z. 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