Research Journal of Veterinary Sciences 1819-1908 2151-786x Science International 10.3923/rjvs.2009.14.20 Ganabadi S. Fakurazi S. Kadir A.A. 1 2009 2 1 Effect of zerumbone on the infiltration major histocompatibility complex class II cells were evaluated in rats with collagen-induced osteoarthritis. The changes in the number of these cells were compared between the corn oil and the zerumbone treated group. The results showed that the number of MHC class II-immunoreactivity was significantly reduced in zerumbone treated group compared to the corn oil group and only type A cells were positive for MHC II staining. Therefore, present results suggest that zerumbone has the property of inhibiting the antigen presenting cells (type A) which is present during inflammation, thus reducing the inflammatory process in osteoarthritis.

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