Research Journal of Phytochemistry1819-34712151-6081Science International10.3923/rjphyto.2016.75.80Nephelium lappaceum L.) Peel]]>PermatasariLina RohmanAbdul 22016102Objectives: Rambutan, Nephelium lappaceum L. is tropical fruit widely distributed in South-East Asia. The consumption of rambutan fruit results in the production of vast amounts of waste from peels of the fruit. Methodology: This study is intended to evaluate the radical activity of extracts and fractions of rambutan peel cultivar simacan and lebak bolus toward 2,2-diphenil-1-picrylhydrazil radical (DPPH) and to correlate its activity with total phenolics and flavonoid contents. Rambutan peel is dried, powdered and macerated using methanol to obtain methanolic extract. The methanolic extract was further subjected to fractionation using petroleum ether and ethyl acetate. The extracts and fractions were evaluated for its radical scavenging activity as well as for determination of phenolics and flavonoids contents. Results: Among extracts and fractions evaluated, ethyl acetate fraction of rambutan peel cultivar lebak bolus has the most active antiradical activity with IC50 value of 2.732 μg mL1. Quercetin was used as positive control with IC50 of 1.998 μg mL1. The ethyl acetate fraction of rambutan peel cultivar lebak bolus also has the highest phenolics and flavonoid contents, accounting of 47.71% (wt/wt) gallic acid equivalent and 29.59% (wt/wt) rutin equivalent, respectively. The correlation between IC50 and phenolics content revealed R2 of 0.594, while R2 for the relationship between IC50 and flavonoid content is 0.323, meaning that phenolics and flavonoid contents contributed to 59.4 and 32.30% of antiradical scavenging activity, respectively. Conclusion: Extract of rambutan peel is potential to be used as antiradical.]]>Lu, J.M., P.H. Lin, Q. Yao and C. Chen,201014840860Carocho, M. and I.C.F.R. Ferreira,2013511525Halliwell, B. and J.M.C. Gutteridge,19892nd Edn.,pp: 416-493pp: 416-493Anagnostopoulou, M.A., P. Kefalas, V.P. Papageorgiou, A.N. Assimopoulou and D. Boskou,2006Citrus sinensis).]]>941925Di Carlo, G., N. Mascolo, A.A. Izzo and F. Capasso,199965337353Alnajar, Z.A.A., M.A. Abdulla, H.M. Ali, M.A. Alshawsh and A.H.A. Hadi,2012Melastoma malabathricum.]]>1735473559Valentao, P., E. Fernandes, F. Carvalho, P.B. Andrade, R.M. Seabra and M.L. Bastos,2002Cynara cardunculus L.) infusion against superoxide radical, hydroxyl radical and hypochlorous acid.]]>5049894993Tachakittirungrod, S., S. Okonogi and S. Chowwanapoonpohn,2007103381388Thitilertdecha, N., A. Teerawutgulrag and N. Rakariyatham,2008Nephelium lappaceum L. extracts.]]>4120292035Thitilertdecha, N. and N. Rakariyatham,2011129247252Nawawi, A., N. Nakamura, M. Hattori, M. Kurokawa and K. Shiraki,1999133741Palanisamy, U.D., L.T. Ling, T. Manaharan and D. Appleton,2011Nephelium lappaceum rind waste and its anti-hyperglycemic activity.]]>1272127Thitilertdecha, N., A. Teerawutgulrag, J.D. Kilburn and N. Rakariyatham,2010Nephelium lappaceum L. and their antioxidant activities.]]>1514531465Rohman, A., S. Riyanto and D. Utari,2006Morinda citrifolia, L) fruit and its fractions.]]>17136142Chun, O.K., D.O. Kim and C.Y. Lee,20035180678072Zou, Y., Y. Lu and D. Wei,2004Hypericum perforatum L. in vitro.]]>5250325039Kuo, C.C., W. Chiang, G.P. Liu, Y.L. Chien and J.Y. Chang et al.,2002Coix lachryma-jobi L. var. ma-yuen Stapf) hulls.]]>5058505855Rohman, A. and S. Riyanto,2005Murraya paniculata (L) Jack) in vitro.]]>16136140Sharma, O.P. and T.K. Bhat,200911312021205Rohman, A., S. Riyanto, N. Yuniarti, W.R. Saputra, R. Utami and W. Mulatsih,2010Pandanus conoideus Lam).]]>1797106Arina, N.B. and A. Rohman,2013Phyllantus urinaria L.]]>2011191124Javanmardi, J., C. Stushnoff, E. Locke and J.M. Vivanco,2003Ocimum accessions.]]>83547550