Research Journal of Phytochemistry1819-34712151-6081Science International10.3923/rjphyto.2016.30.38In vivo Anti-malarial Activity of Cleome viscosa L. Whole Plant]]>ElufioyeT.O. OnojaJ.O. 12016101This study aimed to investigate in vivo anti-malarial effect of methanolic extract of Cleome viscosa whole plant and fractions (n-hexane and ethyl acetate) against early, established and residual malaria infections. The in vivo anti-malarial effect against early infection, curative effect against established infection and prophylactic effect against residual infection were studied in chloroquine-sensitive Plasmodium berghei NK-65 strain infected mice. The results showed that the methanol extract of Cleome viscosa whole plant and partitioned fractions demonstrated significant (p<0.05) dose-dependent anti-malarial activity in all three antimalarial evaluation models thus justifying the inclusion of this plant in recipes for treating malaria.]]>Ahmed, S., M. Sultana, M.M.U. Hasan and I. Azhar,2011Cleome viscosa L.]]>43119122Bose, A., P.J. Smith, C.A. Lategan, J.K. Gupta and S. Si,2010in vitro antiplasmodial activity of Cleome rutidosperma.]]>67315318Chatterjee, A. and S.C. Prakashi,1991Vol. 1, 2nd Edn.,pp: 155pp: 155Elufioye, T.O. and J.O. Onoja,2015Cleome viscosa (Linn.) whole plant.]]>9360369Fernando, S.D., C. Rodrigo and S. Rajapakse,20102010Gupta, P.C. and C.V. Rao,2012Cleome viscosa Linn.]]>3527534Taylor, S.M., J.J. Juliano and S.R. Meshnick,2009Plasmodium falciparum malaria.]]>36118071808Idro, R., K. Marsh, C.C. John and C.R.J. Newton,201068267274Karou, D., M.H. Dicko, S. Sanon, J. Simpore and S.A. Traore,2003Sida acuta Burm. f. (Malvaceae) and Pterocarpus erinaceus Poir. (Fabaceae).]]>89291294Khalid, S.A., H. Duddeck and M. Gonzalez-Sierra,1989Azadirachta indica.]]>52922927Kim, Y.C., H.S. Kim, Y. Wataya, D.H. Sohn and T.H. Kang et al.,2004Sophora flavescens.]]>27748750Kirtikar, K.R. and B.D. Basu,1984Vol. 1, 2nd Edn,pp: 181-185pp: 181-185Klayman, D.L.,198522810491055Mahady, G.B., S. Bhamarapravati, B.A. Adeniyi, B. Doyle, T. Locklear, C. Slover and S.L. Pendland,2006Helicobacter pylori in vitro and in vivo: Support for ethnomedical use.]]>4159165Mokuolu, O.A., E.O. Okoro, S.O. Ayetoro and A.A. Adewara,200776711De Monbrison, F., M. Maitrejean, C. Latour, F. Bugnazet, F. Peyron, D. Barron and S Picot,2006In vitro antimalarial activity of flavonoid derivatives dehydrosilybin and 8-(1;1)-DMA-kaempferide.]]>97102107Muregi, F.W., A. Ishih, T. Miyase, T. Suzuki and H. Kino et al.,2007111190195Nadkarni, A.K.,1982Vol. 1,pp: 351-352pp: 351-352Panduraju, T., B. Parvathi, M. Rammohan and C.S. Reddy,2011Cleome viscosa Linn.]]>34145Parimala Devi, B., R. Boominathan and S.C. Mandal,2004Cleome viscosa Linn. extract in rats and mice.]]>18169172Devi, B.P., R. Boominathan and S.C. Mandal,2003Cleome viscosa Linn. (Capparidaceae) extract in rats.]]>871113Devi, B.P., R. Boominathan and S.C. Mandal,2002Cleome viscosa L. extract in rats.]]>9739742Parimaladevi, B., R. Boominathan and S.C. Mandal,2003Cleome viscosa in mice.]]>74262266Peters, W.,1965Plasmodium berghei Vincke and Lips, 1948. I. Chloroquine resistance.]]>178089Peters, W. and B.L. Robinson,199286455465Ricci, F.,20122012Ryley, J.F. and W. Peters,197064209222Saidu, K., J. Onah, A. Orisadipe, A. Olusola, C. Wambebe and K. Gamaniel,2000Erythrina senegalensis.]]>71275280Sanon, S., E. Ollivier, N. Azas, V. Mahiou and M. Gasquet et al.,2003in vitro antiplasmodial activity of plants used in traditional medicine in Burkina Faso.]]>86143147Sanon, S., N. Azas, M. Gasquet, E. Ollivier and V. Mahiou et al.,2003Pavetta crassipes (K. Schum) and Acanthospermum hispidum (DC), two plants used in traditional medicine in Burkina Faso.]]>90314317Saxena, B.R., M.C. Koli and R.C. Saxena,2000Cleome viscosa L.]]>124750Saxena, S., N. Pant, D.C. Jain and R.S. Bhakuni,20038513141329Shah, G.L., S.S. Yadav and V. Badri Nath, 19834141151Sudhakar, M., C.V. Rao, P.M. Rao and D.B. Raju,2006Cleome viscosa and Gmelina asiatica.]]>774749Tasdemir, D., M. Kaiser, R. Brun, V. Yardley, T.J. Schmidt, F. Tosun and P. Ruedi,2006In vitro, in vivo, structure-activity relationship and quantitative structure-activity relationship studies.]]>5013521364Upadhyay, R.K.,2015Cleome viscosa Linn: A natural source of pharmaceuticals and pesticides.]]>97185WHO.,20102010Valli, M., M. Pivatto, A. Danuello, I. Castro-Gamboa and D.H.S. Silva et al.,20123522782287NIH.,19851985Ishih, A., T. Suzuki, T. Hasegawa, S. Kachi, H.H. Wang and M. Terada,2004In vivo evaluation of combination effects of chloroquine with Cepharanthin® or minocycline hydrochloride against blood-induced chloroquine-resistant Plasmodium berghei NK 65 infections]]>321519MIS.,20102010