Research Journal of Phytochemistry1819-34712151-6081Science International10.3923/rjphyto.2015.16.24 Ampelopsis brevipedunculata and the Isolated Compounds]]>RashedKhaled SaidAtaa FeitosaChistiane Carolina Cardoso SucupiraAna 1201591Medicinal plants are main target for discovery of new drugs for treatment of many diseases. This study evaluated anti-Alzheimer activity of methanol (80%) extract of Ampelopsis brevipedunculata aerial parts and the isolated compounds. Anti-Alzhemier activity for (1) 5, 7-dihydroxy flavanone (pinocembrin), (2) 5, 7-dihydroxy-3, 6, 4'-trimethoxy flavone (santin), (3) Acacetin (4'-methoxy apigenin), (4) Acacetin 7-O-α-rhamnoside, (5) Acacetin 7-O-β-glucoside, (6) Luteolin 7-O-α-rhamnoside, (7) Apigenin 7-O-β-glucoside, (8) Apigenin 7-O-β-glucuronide and A. brevipedunculata extract was detected according to Ellman's method. The results showed that A. brevipedunculata extract and the compounds 2, 6 and 8 were active as anti-Alzheimer agents. The extract showed IC50 = 0.62 μg mL-1 while IC50 = 0.44 μg mL-1, IC50 = 0.32 μg mL-1 and IC50 = 0.56 μg mL-1 for the compounds 2, 6 and 8, respectively, neostigmine (IC50 = 1.87 μg mL-1) was used as positive control. These results showed that A. brevipedunculata extract and the isolated compounds can be promising agents for treatment of Alzheimer's disease in the future.]]>Chattipakorn, S., A. Pongpanparadorn, W. Pratchayasakul, A. Pongchaidacha, K. Ingkaninan and N. Chattipakorn,2007Tabernaemontana divaricata extract inhibits neuronal acetylcholinesterase activity in rats.]]>1106168Cummings, J.L.,20043515667Ellman, G.L., K.D. Courtney, V. Andres Jr. and R.M. Featherstone,196178890Feitosa, C., R.M. de Freitas, N. Luz, M. Bezerra and M. Trevisan,201171783789Moussaoui, F., A. Zellagui, N. Segueni, A. Touil and S. Rhouati,2010Launaea resedifolia (OK) and their antimicrobial activity.]]>49195Fonteles, M.C., R.L. Capelo and V.S.N. Rao,1982Babaei, H., O. Sadeghpour, L. Nahar, A. Delazar and H. Nazemiyeh et al.,2008Amygdalus lycioides Var. horrid.]]>32203208Huxley, A.J., M. Griffiths and M. Levy,1992Vol. 4,Mabry, T.J., K.R. Markham and M.B. Thomas,1970Pages: 354Pages: 354Joshi, N. and D.L. Verma,2012Bergenia stracheyi.]]>2160163Racchi, M., M. Mazzucchelli, E. Porrello, C. Lanni and S. Govoni,200450441451Rhee, K.I., M.R. Van Rijn and R. Verpoorte,200114127131Rodriguez, E., N.J. Carman, G.V.V. Velde, J.H. Mcreynolds, T.J. Mabry, M.A. Irwin and T.A. Geissman,1972Artemisia.]]>1135093514Trevisan, M.T.S., M.Z.B. Bezerra, G.M. Pinheiro, C.M. Feitosa, R. Verpoorte and R.B. Filho,2006Kalanchoe species.]]>29415418Watkins, P.B., H.J. Zimmerman, M.J. Knapp, S.I. Gracon and K.W. Lewis,1994271992998Xu, Z., X. Liu and G. Xu,1995Ampelopsis brevipedunculata.]]>20484486Yabe, N. and H. Matsui,2000Ampelopsis brevipedunculata (Vitaceae) extract inhibits a progression of carbon tetrachloride-induced hepatic injury in the mice.]]>7493498Yadav, R.N.S. and M. Agarwala,201131014Yoshiteru, O., U. Yuji and H. Hiroshi,1990Ampelopsis brevipedunculata VAR. Hancei.]]>4551215126Li, Y.L., J. Li, N.L. Wang and X.S. Yao,2008Bidens parviflora willd.]]>1319311941