Research Journal of Phytochemistry1819-34712151-6081Science International10.3923/rjphyto.2011.70.79Cucurbita pepo]]>GillN.S. BaliM. 2201152The present study has reported the isolation, characterization, antioxidant and antiulcer activity of a new triterpenoid extracted from Cucurbita pepo seeds. The seed extract was subjected to column chromatography for the isolation of constituents. The isolated compound was characterized by Infra red, 1Hydrogen Nuclear Magnetic Resonance, 13Carbon Nuclear Magnetic Resonance which allow the identification of isotopic hydrogen and carbon atoms in a molecule, respectively. The isolated compound was a tetracyclic triterpenoid which possesses basic cucurbitacin skeleton characterized as 19-(10→9β)-abeo-10α-lanost-5-ene. The isolated compound showed maximum antioxidant activity i.e. 72.8±0.15% by 1, 1 diphenyl -2- picryl hydrazyl method at 300 μg mL-1 as compared to ascorbic acid. Further, it was evaluated for anti ulcerogenic activity, extracted triterpenoid showed optimum percentage inhibition i.e., 55.7, 67.1 and 59.1% by Pyloric Ligation, Water Immersion Stress and NSAID (Indomethacin) induced ulcer method at 300 μg mL-1 dose in rats. It can be inferred from the above study that the extracted tetracyclic triterpenoid have potent anti-ulcer activity due to its antioxidant potential and can be used as natural antiulcerogenic agent.]]>Akihisa, T., H. Tokuda, E. Ichiishi, T. Mukainaka and M. Toriumi et al.,2001173914Applcquist, W.L., B. Avula, B.T. Schancberg, Y.H. Wang and I.A. Khan,2006Cucurbita species grown in a common (shared) garden.]]>19606611Atuonwu, A.C. and E.N.T. Akobundu,2010Cucurbita pepo) seed flour.]]>9672677Bernard, S.A. and O.A. Olayinka,2010428212826Bhujbal, S.S., S.S. Chitlange, A.A. Suralkar, D.B. Shinde and M.J. Patil,2008Celosia argentea linn.]]>25254Bisognin, D.A.,200232715723Bombardelli, E. and P. Morazoni,1997Cucurbita pepo L.]]>68291302Bose, M., V.M. Motghare, G.N. Dakhale and A.V. Turankar,2003559195Fu, C., H. Shi and Q. Li,2006617077Chanda, S., R. Dave and M. Kaneria,2011In vitro antioxidant property of some Indian medicinal plants.]]>5169179Chen, J.C., M.H. Chiu, R.L. Nie, G.A. Cordell and S.X. Qiu,200522386399Chen, J.C., W.Q. Liu, L. Lu, M.H. Qiu and Y.T. Zheng et al.,2009Momordica charantia.]]>70133140Chen, C.R., Y.W. Liao, L. Wang, Y.H. Kuo and H.J. Liu et al.,2010Momordica charantia and their cytoprotective activity in tert-butyl hydroperoxide-induced hepatotoxicity of HepG2 cells.]]>5816391642Das, D. and R.K. Banerjee,1993125115125Dengiz, G.O. and N. Gursan,2005Momordica charantia L. (Cucurbitaceae) on indomethacin induced ulcer model in rats.]]>168588Ge, S., D.C. Wang, L.J. Wu and X.M. Deng,2006Cucurbita pepocv Dayangua.]]>235559Goswani, S., S. Jain and D. Santani,199749195199Wang, J., X. Zhou, Y. Cao, J. Xiao, E. Ma, Y. Deng and D. Chen,2007Cucurbitacin Liposome for injection both in vitro and in vivo.]]>298103Hayase, M. and K. Takeuchi,198631166171Huang, X.E., K. Hirose, K. Wakai, K. Matsuo and H. Ito et al.,20045419427Khayum, M.A., K. Nandakumar, T.S. Gouda, S.M. Khalid, V.N. Rao and S.M.S. Kumar,2009Tinospora malabarica (Lamk.).]]>1885890Kitagawa, H., M. Fjuwara and Y. Osumi,197977298302Sunilson, J.A.J., M. Muthappan, A. Das, R. Suraj, R. Varatharajan and P. Promwichit,2009Coccinia grandis leaves against carbon tetrachloride induced hepatic injury in rats.]]>5222227Oka, S., K. Ogino, T. Hobara, S. Yoshimura, Y. Okazaki, T. Takemoto and Y. Iida,199119799102Rajkapoor, B., R. Anandan and B. Jayakar,2002Nigella sativa Linn. against gastric ulcer in rats.]]>82177179Sachin, S.S. and R.J. Archana,2009Erythrina indica Lam. leaves in experimental animals.]]>6396401Shay, H., S.A. Komarow, S.S. Fels, D. Meranze, M. Gruenstein and H. Siplet,194554361Shah, B.N., A.K. Seth and R.V. Desai,2010Lagenaria siceraria: A review.]]>9152157Sreejayan, N. and M.N. Rao,199646169171Szelenyi, I. and K. Brune,198833865871Takagi, K., S. Okabe and R. Saziki,196919418426Yin, D., N. Wakimoto, H. Xing, D. Lu and T. Huynh et al.,200812313641375Karim, A., M.N. Sohail, S. Munir and S. Sattar,20117419439Toyama, J., H. Tanaka, A. Horie, T. Uchiyama and R. Akashi,2008Momordica charantia and the inter-specific differences of hemagglutinating activity in Cucurbitaceae.]]>7647653