Research Journal of Phytochemistry1819-34712151-6081apsasia10.3923/rjphyto.2011.130.135Coffea brivipes HIERN Extracts]]>OladosuI.A.OgundajoA.L.AiyelaagbeO.O.EmenyonuN.2201152The present study seeks to evaluate the medicinal relevance of the Coffea brivipes extracts against some clinically identified strains of Mycobacterium tuberculosis, using standard methods of microbial sensitivity test and phytochemical analysis. The whole plant samples of Coffea brivipes were extracted with absolute ethanol. The ethanol extract of Coffea brivipes HIERN (RUBIACEA) was then macerated with hexane, chloroform and ethyl acetate successively to obtain hexane, chloroform and EtOAc soluble extracts. The extracts were screened for their phytochemical composition and anti-bacterial activities. The phytochemical results depicted the presence of carbohydrate, alkaloids, tanins, sterols, flavonoids, resins and phenols distributed in varying degrees. The antibacterial activity of the extracts against Mycobacterium tuberculosis (MTB 050 and 303) were carried out using the egg enriched Lowenstein-Jansen medium with isoniazid, dihydrostreptomycin, enthanbutol and rifampicin as standard control drugs. The extracts showed different anti-bacterial activities at 10-2 and 10-4 bacteria load. MTB 050 strains showed resistance to rifampicin at both innoculum. Hexane and ethylacetate extracts of C. brivipes at 5 mg mL-1 exhibited good anti-bacterial activities against this rifampicin resistance strain. The result suggest that the hexane and ethylacetate extracts of Coffea brivipes can serve as a good cut for the replacement of rifampicin as an anti-Tb drug.]]>Burkill, H.M.,2000Useful Plants of West Tropical Africa Volume 4: Families M-R.2nd Edn.,pp: 981pp: 981Alzoreky, N. and K. Nakahara,2001Food Sci. Technol. Res.,7141144Cox, R.,2004Mycobacterium tuberculosis, Streptomyces coelicolor A3(2) and Escherichia coli B/r: An integrative theoretical approach.]]>Microbiology,15014131426WHO,2006Global and regional incidence.2006Sofowora, A.,1993Medicinal Plants and Traditional Medicine in Africa.2nd Edn.,Pages: 289Pages: 289Trease, G.E. and W.C. Evans,1989Pharmacognosy.13th Edn.,pp: 176-180pp: 176-180Ayoola, G.A., H.A. Coker, S.A. Adesegun, A.A. Adepoju-Bello, K. Obaweya, E.C. Ezennia and T.O. Atangbayila,2008Trop. J. Pharm. Res.,710191024Hwang, E., B.T. Ahn, H.B. Lee, Y.K. Kim and K.S. Lee et al.,2001Saccharomyces cerevisae by tannins and related compounds.]]>Planta Med.,67501504Claus, E.P., V.E. Tyler and L.R. Brady,1990Pharmacognosy.6th Edn.,pp: 79-137pp: 79-137Nikhila, K.R., V.B. Sureshkumar, K.V. Mohanan and A. Santaram,2008Coffea canephora Pierre ex Froehner).]]>Int. J. Plant Breed. Genet.,24750Sureshkumar, V.B., N.S. Prakash and K.V. Mohanan,2010Coffea racemosa x Coffea canephora var. robusta hybrids in relation to certain critically important characters.]]>Int. J. Plant Breed. Gene.,43035Kufa, T. and J. Burkhardt,2011Int. J. Bot.,76372Daglia, M., A. Papetti, P. Grisoli, C. Aceti, V. Spini, C. Dacarro and G. Gazzani,2007J. Agric. Food Chem.,551020810213Andrade, P.B., R. Leitao, R.M. Seabra, M.B. Oliveira and M.A. Ferreira,1998Coffea canephora var. robusta and Coffea Arabica.]]>Food Chem.,61511514CDC,2003Morb. Mortal. Wkly. Rep.,52329332Imam, F., M.K. Anwer, M. Iqbal, S. Alam, K.U. Khayyam and M. Sharma,2010Int. J. Pharmacol.,6755783Nikalje, A.G. and P. Mudassar,2011Mycobacterium tuberculosis: A brief review.]]>Asian J. Biol. Sci.,4101115Nwachukwu, N.C., A. Orji, I. Kanu and H.C. Okereke,2009Asian J. Epidemiol.,21319Simkin, A.J., H. Moreau, M. Kuntz, G. Pagny, C. Lin, S. Tanksley and J. McCarthy,2008Coffea canephora and Coffea arabica.]]>J. Plant Physiol.,16510871106Koshiro, Y., X.Q. Zheng, M.L. Wang, C. Nagai and H. Ashihara,2006Coffea arabica and Coffea canephora fruits.]]>Plant Sci.,171242250