Research Journal of Nanoscience and Nanotechnology1996-5044xxxx-xxxxAsian Network for Scientific Information10.3923/rjnn.2011.60.74SarafSwarnlata GhoshAvijit KaurChanchal DeepSarafShailendra 2201112Targeting of drugs and bioactives to lymphatic system is very challenging and it depends upon the complex physiology of the lymphatic system. Targeting helps in achieving the aim of direct contact of drug with the specific site, decreasing the dose of the drugs and minimising the adverse effects caused by them. Use of nanosystem has promoted the lymphatic targeting; but still there are challenges of detecting specific sites, maintaining desired action, crossing all the physiological barriers. These hurdles could be overcome by the use of modified nanosystems achieved by the surface engineering. 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