Research Journal of Medicinal Plants1819-34552151-7924Science International10.3923/rjmp.2021.36.45Solanum rugosum (Solanaceae) on Skin and Eye]]>CalixteBahi N’dri MarcellineTapé-Adiko AminataAkoubet-Ouayogode MoribaToure Aholia Jean-BaptisteAdepo Venance MartialSay Ahmont Landry ClaudeKablan Wacothon KarimeCoulibaly Bamba DiénébaKone 12021151Background and Objective: The root bark of Solanum rugosum is used in traditional Ivorian medicine to treat certain eye diseases such as allergic, bacterial and viral conjunctivitis. Thus, the objective of this study was to highlight the presence of alkaloids in the root bark of Solanum rugosum and evaluate in vivo the acute oral toxicity as well as the skin and eye tolerances of the extract. Materials and Methods: The powdered root bark was refluxed for 15 min in distilled water. The chemical study of the extract was made by LC-ESI-Q-TOF-MS. For acute oral toxicity in mice, skin and eye tolerance OECD methods 423, 404, 405 were used, respectively. Results: Four alkaloids including lycorine, corynanthine, corynantheine and mitrinermine were found in the root bark. The cutaneous and ocular tolerance tests carried out demonstrated good cutaneous and ocular tolerances of the extract. Conclusion: The findings of the study revealed that the total aqueous extract of the root bark of Solanum rugosum is not toxic and is well tolerated.]]>Marcelline, A.N., O.A. Timothée, S.V. Martial, A.O. Aminata, K.A. Armand and K.A.L. Claude,2020In vivo antistaphylococcal activity evaluation of Ocimum gratissimum Linn. (Lamiaceae) ophthalmic ointment.]]>324457Fraunfelder, F.W.,2004138639647Pomilio, A.B., E.M. Falzoni and A.A. Vitale,20083593628 Scholt, S., L. MacMorris, F. Krogmann and G.U. Auffarth,201915158Waithaka, P.N., B.M. Githaiga, E.M. Gathuru and M.F. Dixon,2019 Solanum incanum root extracts on bacteria pathogens isolated from portable water in egerton university, Kenya.]]>61924Maregesi, S.M., C.W. Messo and J. Mathias,201767583Zhang, Z., Y. Zhou, Z. Xie, T. Chen, Y. Gu, S. Lu and Z. Wu,20162016Rocha, J., V. Royo, E. Menezes and D.D. Oliveira,2019Solanum L. (Solanaceae).]]>114750Ferrer, C., O. Malato, A. Agüera and A.R. Fernandez-Alba,201258160Bhosale, U.A., R. Yegnanarayan, P. Pophale and R. Somani,2012Achyranthes aspera Linn. on experimental animal model for inflammation.]]>31202206Kaur, I.P., C. Rana, M. Singh, S. Bhushan, H. Singh and S. Kakkar,201228484496Louhimies, S.,200230217219Ptak, A., A. El Tahchy, F. Dupire, M. Boisbrun and M. Henry et al.,2008in vitro extracts of Leucojum aestivum.]]>72142147Wang, Y.H., B. Avula, M. Wang, S. Sagi and P. Cohen et al.,20142014Long, J., Y. Wang, C. Xu, T. Liu, G. Duan and Y. Yu,201866527534Kumar, P., B. Sharma and N. Bakshi.,2009Solanum dulcamara L.]]>23719723Jasim, H., A.O. Hussein, I.H. Hameed and M.A. Kareem,2015Solanum nigrum using gas chromatography mass spectrometry (GC-MS).]]>75672Zubaida, Y., W. Ying and E. Baydoun,2013Solanum torvum swartz.]]>3152160Lamoral-Theys, D., A. Andolfi, G.V. Goietsenoven, A. Cimmino and B.L. Calvé et al.,20095262446256Kretzing, S., G. Abraham, B. Seiwert, F.R. Ungemach, U. Krügel and R. Regenthal,201157117124Hu, M., S. Peng, Y. He, M. Qin and X. Cong et al.,201561534815361Sheludko, Y.V., I.M. Gerasymenko and H. Warzecha,2018Nicotiana benthamiana provides a possibility for rapid substrate testing and production of novel compounds.]]>2018Stærk, D., E. Lemmich, J. Christensen, A. Kharazmi, C.E. Olsen and J.W. Jaroszewski,200066531536Li, P.Y., X.R. Zeng, J. Cheng, J. Wen, I. Inoue and Y. Yang,2013386973982de Souza, G.R., A.C.A.X. De-Oliveira, V. Soares, L.F. Chagas, N.S. Barbi, F.J.R. Paumgartten and A.J.R. da Silva,2019Solanum paniculatum leaf extract.]]>110129138Orqueda, M.E., M. Rivas, I.C. Zampini, M.R. Alberto and S. Torres et al.,2017Solanum betaceum), an argentine native fruit. Phenolic fractions affect key enzymes involved in metabolic syndrome and oxidative stress.]]>2167079Alexis, K.T., K.B. Antoine, A.M. Rosine, K.K. Christian, M.B.J. Akhanovna and B. Yves-Alain,2020Solanum rugosum Dunal from Côte d'Ivoire.]]>121333313339Fokou, P.V.T., A.K. Nyarko, R. Appiah-Opong, L.R.T. Yamthe, P. Addo, I.K. Asante and F.F. Boyom,2015172297311