Research Journal of Medicinal Plants1819-34552151-7924Science International10.3923/rjmp.2020.119.124Andrographis panniculata Ness, Curcuma xanthoriza Roxb and Cinnamommum burmanii as Appetite Enhancer with Low Infertility Risk]]>Putri AbriyantiSeptin Dewi TamayantiWahyu SoegiantoLisa Sahrial HamidIwan Megawati WidharnaRatna 32020143Background and Objectives: The main ingredients of Sambiloto (Andrographis panniculata Ness), Temulawak (Curcuma xanthoriza Roxb) and Kayu Manis (Cinnamomum burmanii) are andrografolid, curcumin and cinnamaldehyde, respectively. These compounds, in individual usage were reported as appetite enhancer in Wistar rats, but they caused infertility in male rats. This study therefore aimed to test the effectivity improvement of these compounds as appetite and fertility enhancer when administered as combination. Materials and Methods: A total of 36 male Wistar rats were divided into several groups including: treatment groups that were administered: Sambiloto-Temulawak-Kayu manis (STK), Sambiloto-Temulawak (ST), Sambiloto-Kayu manis (SK), Temulawak-Kayu manis (TK), a positive control group was Tracetate treated and a group that was treated with vehicle. At the end of 28 days treatment, rats were sacrificed, testicle and spermatozoa were collected. The impairment of testicle tubules and reduction of primary spermatocyte amount were observed. Results: The body weights of rats were increased in all the treatment groups as compared to negative control group. Similar trend was observed in the percentage of food intake. Wistar rats in Sambiloto-Temulawak-Kayu manis (STK) group showed the lowest number of both spermatozoa viability of 41.33±4.01% (0.0004) and primary spermatocyte count of 43.70±6.91 cells (0.0044), but no impairment in seminiferous tubules was observed. Conclusion: The combination of sambiloto, temulawak and kayu manis (60:140:50 mg kg1 b.wt.) increased body weight and food intake of male rats in this study. Sambiloto-Temulawak (ST) group shown as the best combination to increase body weight of rats with the lowest infertility effect.]]>Egecioglu, E., K.P. Skibicka, C. Hansson, M. Alvarez-Crespo and P.A. Friberg et al.,201112141151Waskett, C.,20042004pp: 128-158pp: 128-158McDonald, R.B. and R.C. Ruhe,20042004pp: 49-62pp: 49-62Wilson, M.M.G. and J.E. Morley,20039517281736Limananti, A.I. and T.A. Triatna,2003Cekok as a cure for appetite stimulant in children: An ethnomedicine review].]]>71120, (In Indonesian)Khandke, D.A.,2011145407413Ghelani, H., V. Razmovski-Naumovski, D. Chang and S. Nammi,20192019Kim, S.H., S.H. Hyun and S.Y. Choung,2006104119123Kamaruzaman, K.A. and M.M. Noor,2017Andrographis paniculata methanol extract in Sprague Dawley rats.]]>46225232Firdaus, H., T. Harjana and Suhandoyo,2012Curcuma xanthorrhiza R.) and brotowali (Tinospora crispa L.) extract towards rats uterus (Rattus norvegicus L.)].]]>2012Maheshwari, R.K., A.K. Chauhan, A. Gupta and S. Sharma,20132131145Allan, J.J., M.P. Pore, M. Deepak, B. Murali, A.S. Mayachari and A. Agarwal,2009Andrographis paniculata in male Wistar rats.]]>28308317Turk, G., A. Atessahin, M. Sonmez, A.O. Ceribasi and A. Yuce,20088914741481Berndston, W.E.,197744818833Ciardi, C., M. Jenny, A. Tschoner, F. Ueberall and J. Patsch et al.,2012in vitro.]]>107826833McLachlan, R.I., L. O'Donnell, S.J. Meachem, P.G. Stanton, D.M. de Kretser, K. Pratis and D.M. Robertson,200257149179Huhtaniemi, I.,2010181273288Sloane, E.,20041st Edn.,Sariozkan, S., G. Turk, M. Guvenc, A. Yuce, S. Ozdamar, F. Canturk and A.H. Yay,2016C. zeylanicum) Bark oil against taxanes-induced damages in sperm quality, testicular and epididymal oxidant/antioxidant balance, testicular apoptosis and sperm DNA integrity.]]>68481494Modaresi, M., M. Messripour and R. Rajaei,2009146777Yuce, A., G. Turk, S. Ceribasi, M. Sonmez, M. Ciftci and M. Guvenc,2013Cinnamomum zeylanicum) bark oil on testicular antioxidant values, apoptotic germ cell and sperm quality.]]>45248255Yuce, A., G. Turk, S. Ceribasi, M. Guvenc and M. Ciftci et al.,2014Cinnamomum zeylanicum) bark oil in the prevention of carbon tetrachloride-induced damages on the male reproductive system.]]>46263272