Research Journal of Medicinal Plants1819-34552151-7924Science International10.3923/rjmp.2016.79.88Anthocleista vogelii Ethanolic Root Extract in Alloxan-Induced Diabetic Rats]]>SundayRita M. IlesanmiOlapade R. ObuotorEfere M. 12016101This study was carried out to evaluate the potential anti-diabetic effect of Anthocleista vogelii ethanolic root extract in alloxan-induced diabetic rats. Albino rats of both sexes were randomly divided into five groups with five rats each. Group 1 (control; 10 mL kg1 distilled water), group 2-4 (100, 200 and 400 mg kg1A. vogelii ethanolic root extract) and group 5 (5 mg kg1 glibenclamide). Diabetes was induced physiologically using 10 g kg1 glucose p.o. and chemically using 150 mg kg1 alloxan i.p. Fasting blood glucose levels of the diabetic rats were determined at intervals of 30, 60, 120 and 240 min in glucose loaded rats and on days 4, 7, 10 and 14 in alloxan-induced diabetic rats. After two weeks, the levels of serum cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, alanine aminotransferase, aspartate amino transferase and creatinine of all the groups were analyzed. The LD50 of A. vogelii ethanolic root extract was ≥5000 mg kg1 (p.o.). The extract exerted a significant (p<0.05) reduction in Fasting blood glucose levels, serum cholesterol, triglyceride, low density lipoprotein, creatinine, alanine aminotransferase and aspartate aminotransferase levels and an increase in serum high density lipoprotein levels when compared to the control. The extract also elicited a significant decrease in body weight, food and water intake in diabetic treated rats. The results show that A. vogelii ethanolic root extract have anti-diabetic and anti-hyperlipideamic effect when administered for 14 days in alloxan-induced diabetic rats.]]>Abbel, L.L., B.B. Levey, B.B. Brodie and F.E. Kendall,1952195357366Adebajo, A.C., E.O. Olawode, O.R. Omobuwajo, S.A. Adesanya and F. Begrow et al.,2007Stachytarpheta cayennensis leaf.]]>73241250Anyanwu, G.O., E.C. Onyeneke, U. Usunobun and A.J. Adegbegi,2013Anthocleista vogelii root bark ethanolic extract on weight reduction in high carbohydrate diet induced obesity in male wistar rats.]]>7225232ATSDR.,19971997Balde, N., A. Youla, M.D. Balde, A. Kake, M.M. Diallo, M.A. Balde and D. Maugendre,200632171175Balkau, B., M.A. Charles and E. Eschwege,20002229234Bartels, H., M. Bohmer and C. Heierli,197237193197Bosenberg, L.H. and D.G. van Zyl,200848088Etuk, E.U.,20101130134Gupta, K.R., N.A. Kesari, G. Watal, P.S. Murthy, R. Chandra, K. Maithal and V. Tandon,2005Annona squamosa (L.) in experimental animal.]]>8812441254Jackson, J.E. and R. Bressler,198122211245Jacobs, D.S., B.L. Kasten, W.R. DeMott and W.L. Wolfson,19902nd Edn.,Pages: 219Pages: 219Jegede, I.A., J.A. Ibrahim and O.F. Kunle,2011Anthocleista vogelii (Planch).]]>561366139Katerere, D.R. and J.N. Eloff,20052005pp: 203-218pp: 203-218Koditschek, L.K. and W.W. Umbreit,19699810631068Kruger, D.F. and M.A. Gloster,20046414191432Lenzen, S. and R. Munday,1991N-methyl derivatives and a comparison with ninhydrin.]]>4213851391Lorke, D.,198354275287Lu, F. and L.Y. Foo,19951995Murray, R.K., D.K. Granner, P.O. Mayes and V.W. Rodwell,200326th Edn.,Pages: 693Pages: 693Mythili, M.D., R. Vyas, G. Akila and S. Gunasekaran,200463274281Nabeel, M.A., K. Kathiresan and S. Manivannan,2010Ceriops decandra in alloxan-induced diabetic rats.]]>297103Nathan, D.M., P.A. Cleary, J.Y. Backlund, S.M. Genuth and J.M. Lachin et al.,200535326432653Okokon, J.E. and P.A. Nwafor,2009Croton zambesicus.]]>1217478Osadebe, P.O., P.F. Uzor., E.O. Omeje., M.O. Agbo and W.O. Obonga,2014Anthocleista vogelii (Planch) Stem Bark.]]>1314371443Owolabi, O.J., F.C. Amaechina and M. Okoro,2011Newboulda laevis on blood glucose levels of diabetic rats.]]>10249254Reitman, S. and S. Frankel,1957285663Richmond, W.,1973Nocardia sp. and its application to the enzymatic assay of total cholesterol in serum.]]>1913501356Roeschlau, P., E. Bernt and J.W. Gruber,197412403407Schirmeister, J., H. Willmann and H. Kiefer,19648910181023, (In German)Schmidt, E. and F.W. Schmidt,19633152Tietz, N.W.,19902nd Edn.,pp: 554-556pp: 554-556Trinder, P.,196962427VanDeKoppel, S., H.M. Choe and B.V. Sweet,200814363380Zhang, X.F. and B.K.H. Tan,2000Gynura procumbens on serum glucose, cholesterol and triglyceride levels in normal and streptozotocin-induced diabetic rats.]]>41913Mogale, M.A., H.M. Mkhombo, S.L. Lebelo, L.J. Shai, M.A. Chauke and A. de Freitas, 2012Clausena anisata (Wild) Hook leaf extracts on selected diabetic related metabolizing enzymes.]]>642004207