Research Journal of Medicinal Plants1819-34552151-7924Science International10.3923/rjmp.2016.340.348Colocasia esculenta
[L. Schott] in Albino Rats]]>AzubikeN.C. AchukwuP.U. OkwuosaC.N. NwachukwuD.C. OnwukweO.S. OnyemelukweA.O. 52016105Background: Colocasia esculenta leaves are employed traditionally in the treatment of hepatic ailments, constipation, stomatitis, among
others. Objective: This study reports the sub-acute toxicity effects of C. esculenta (CE) crude aqueous leaves extracts in albino rats.
Methodology: Daily doses of 400 and 800 mg kg1 b.wt. of crude aqueous extracts of the fresh and dried leaves of CE were administered
orally to different sets of rats for 28 days. Body weights, Relative Organ Weights (ROW), haematological analysis, serum biochemical assay
and histopathological changes of vital organs were used to evaluate the toxic effects of the extracts after treatments. Results: Results
revealed that treatment with CE causes adverse effects on body weight. The tested doses did not provoke significant changes in
haematological and biochemical parameters of rats except an increase in alkaline phosphatase of treated rats (p<0.05). The ROW were
normal except those of the kidneys and testes. Mild histopathological changes were observed in kidney, lungs and intestines.
Conclusion: Results provided evidence that sub-acute oral administration of crude aqueous extracts of CE leaves at doses lower than
1000 mg kg1 may not exert toxic effects on haematological and some biochemical parameters but may exert selective toxicity in few
visceral organs.]]>Gohl, B.,1993Lewu, M.N., P.O. Adebola and A.J. Afolayan,2009Colocasia esculenta (L.) Schott in KwaZulu-Natal province of South Africa.]]>816191622Azubike, N.C., P.U. Achukwu and C.N. Okwuosa,2012Colocasia esculenta.]]>151078310796Tuse, T.A., U.N. Harle and V.V. Bore,2009Colocasia antiquorum against experimentally induced liver injury in rats.]]>799112Awasthi, C.P. and A.B. Singh,2000Colocasia and Alocasia collections.]]>34117121Devarkar, V.D., V.R. Marathe and D.P. Chavan,201111317332Kumawat, N.S., S.P. Chaudhari, N.S. Wani, T.A. Deshmukh and V.R. Patil,2010Colocasia esculenta leaves in alloxan induced diabetic rats.]]>212461249Grindley, P.B.A., F. Omoruyi, H.N. Asemota and E.Y.S.A. Morrison,2002Dioscorea cayenensis) or dasheen (Colocasia esculenta).]]>22333341Boban, P.T., B. Nambisan and P.R. Sudhakaran,20069610211029Patil, B.R. and H.M. Ageely,2011Colocasia esculenta leaf Juice against CCl4 and acetaminophen mediated cell damage.]]>2141149Biren, N.S., B.S. Nayak, S.P. Bhatt, S.S. Jalalpure and A.K. Seth,2007Colocasia esculenta.]]>15228228Vasant, O.K., B.G. Vijay, S.R. Virbhadrappa, N.T. Dilip, M.V. Ramahari and B.S. Laxamanrao,2012Colocasia esculenta Linn. leaves in experimental paradigms.]]>11621634Yang, A.H. and K.W. Yeh,2005Colocasia esculenta cv. Kaosiung no. 1).]]>221493501Nair, R., T. Kalariya and S. Chanda,2005294147INSA.,2000Lewis, S.M., N.J. Bain and I. Bates,20062006pp: 26-57pp: 26-57Roy, A.V.,197016431436Reitman, S. and S. Frankel,1957285663Sood, R.,20096th Edn.,pp: 1413-1431pp: 1413-1431Baker F.J., R.E. Silverton and C.J. Pallister,19987th Edn.,Pages: 448Pages: 448Hussain, M., G. Norton and R.J. Neale,1984Colocasia esculenta (L.) Schott.]]>3511121119Iwuoha, C.I. and F.A. Kalu,1995Colocasia esculenta and Xanthosoma sagittifolium) tuber flours as affected by processing.]]>546166Agwunobi, L.N., P.O. Angwukam, O.O. Cora and M.A. Isika,2002Colocasia esculenta (taro cocoyam) in the diets of weaned pigs.]]>34241247Tucci, S.A.,20103748763Han, L.K., R. Nose, W. Li, X.J. Gong and Y.N. Zheng et al.,2006Kochia scoparia fruit.]]>20877882Santos, A.P., M.M. Rogero and D.H.M. Bastos,20102195212Pfeiffer, C.J.,196813220227Nisha, A., S.P. Muthukumar and G. Venkateswaran,2009Mortierella alpina biomass in albino rats-A subchronic study.]]>53186194Angervall, L. and E. Carlstrom,19634254259Peters, J.M. and E.M. Boyd,196690354360Stevens, M.T.,19765311318Abotsi, W.K.M., G.K. Ainooson, E.B. Gyasi and W.K.M. Abotsi,2011Hilleria latifolia (Lam.) H. Walt. (Phytolaccaceae) in rodents.]]>222735Steenkamp, V. and M.J. Stewart,200527270277Abdualmjid, R.J. and C. Sergi,201316376404Akdogan, M., I. Kwlwnc, M. Oncu, E. Karaoz and N. Delibas,2003Mentha piperita L. and Mentha spicata L. on kidney tissue in rats.]]>22213219Chand, N., F.R. Durrani, S. Ahmad and A. Khan,2011Berberis lycium in broiler chicks.]]>9117371745Nanji, A.A.,198349241245Badgu, N. and R. Merugu,20134371379Amacher, D.E.,200221253262El Hilaly, J., Z.H. Israili and B. Lyoussi,2004Ajuga iva in experimental animals.]]>914350Bidhe, R.M. and S. Ghosh,20046716