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  <front>

    <journal-meta>

      <journal-title>Research Journal of Medicinal Plants</journal-title>

      <issn pub-type="ppub">1819-3455</issn>

      <issn pub-type="epub">2151-7924</issn>

      <publisher>

        <publisher-name>Science International</publisher-name>

      </publisher>

    </journal-meta>


    <article-meta>

      <article-id pub-id-type="doi">10.3923/rjmp.2013.119.124</article-id>


      <title-group>

        <article-title><![CDATA[Quantification of Trace Elements in Some Multi-herbal Formulations]]></article-title>

      </title-group>


      <contrib-group>

        <contrib contrib-type="author" xlink:type="simple">


          <name name-style="western">

            <surname>Ray</surname>

            <given-names>D.K.</given-names>

          </name>


          <name name-style="western">

            <surname>Jena</surname>

            <given-names>S.</given-names>

          </name>


        </contrib>

      </contrib-group>


      <pub-date pub-type="collection">


        <month>2</month>




        <year>2013</year>

      </pub-date>


      <volume>7</volume>

      <issue>2</issue>


      <abstract><![CDATA[<p>Popularity of herbal products is increasing worldwide for control and management 
  of several diseases and disorders. They are studied extensively for their organic 
  macro and micro nutrients. However less emphasis is given to their inorganic 
  counterparts or Trace elements. To evaluate the presence of such inorganic micronutrients 
  or trace elements in some herbal formulations, present study is undertaken. 
  Elemental analysis was carried out by using Particle induced X-ray Emission 
  (PIXE) technique. Four multi-herbal formulations commercially available for 
  control and management of Diabetes mellitus were procured for the present study. 
  Elements like potassium, calcium, vanadium, manganese, iron, copper, zinc, rubidium, 
  strontium have been quantified in these herbal formulations. They are found 
  to contain varied proportions of these elements. Although rubidium and strontium 
  have been detected in these multi-herbal formulations, the role of these elements 
  in management of diabetes mellitus is lacking and needs further detailed investigation. 
  The present study may be helpful for better understanding of the possible curative 
  effect of the trace elements present in the herbal formulations for management 
  of the diabetes mellitus. The PIXE method constitutes a promising analytical 
  tool, which has the potential for routine testing of herbal products.</p>]]></abstract>


    </article-meta>

  </front>


  <ref-list>




      <ref id="922428">

        <label>1</label>

        <citation citation-type="journal" xlink:type="simple">

          <person-group person-group-type="author">

            <name name-style="western">

              <surname>Abdelatif, A.M., M.Y. Ibrahim and A.S. Mahmoud,</surname>

              <given-names></given-names>

            </name>

          </person-group>

          <year>2012</year>

          <article-title><![CDATA[Antidiabetic effects of fenugreek (<I>Trigonella foenum-graecum</I>) seeds in the domestic rabbit (<I>Oryctolagus cuniculus</I>).]]></article-title>

          <source>Res. J. Med. Plant,</source>

          <volume>6</volume>

          <fpage>449</fpage>

          <lpage>455</lpage>

        </citation>

      </ref>


















      <ref id="159133">

        <label>2</label>

        <citation citation-type="journal" xlink:type="simple">

          <person-group person-group-type="author">

            <name name-style="western">

              <surname>Abou-Seif, M.A. and A.A. Youssef,</surname>

              <given-names></given-names>

            </name>

          </person-group>

          <year>2004</year>

          <article-title><![CDATA[Evaluation of some biochemical changes in diabetic patients.]]></article-title>

          <source>Clin. Chim. Acta,</source>

          <volume>346</volume>

          <fpage>161</fpage>

          <lpage>170</lpage>

        </citation>

      </ref>


















      <ref id="876911">

        <label>3</label>

        <citation citation-type="journal" xlink:type="simple">

          <person-group person-group-type="author">

            <name name-style="western">

              <surname>American Diabetes Association,</surname>

              <given-names></given-names>

            </name>

          </person-group>

          <year>2004</year>

          <article-title><![CDATA[Diagnosis and classification of diabetes mellitus.]]></article-title>

          <source>Diabetes Care,</source>

          <volume>27</volume>

          <fpage>S5</fpage>

          <lpage>S10</lpage>

        </citation>

      </ref>


















      <ref id="1081172">

        <label>4</label>

        <citation citation-type="journal" xlink:type="simple">

          <person-group person-group-type="author">

            <name name-style="western">

              <surname>Aschner, J.L. and M. Aschner,</surname>

              <given-names></given-names>

            </name>

          </person-group>

          <year>2005</year>

          <article-title><![CDATA[Nutritional aspects of manganese homeostasis.]]></article-title>

          <source>Mol. Aspects Med.,</source>

          <volume>26</volume>

          <fpage>353</fpage>

          <lpage>362</lpage>

        </citation>

      </ref>


















      <ref id="1126206">

        <label>5</label>

        <citation citation-type="journal" xlink:type="simple">

          <person-group person-group-type="author">

            <name name-style="western">

              <surname>Bennett, W.L., O.A. Odelola, L.M. Wilson, S. Bolen and S. Selvaraj <i>et al</i>.,</surname>

              <given-names></given-names>

            </name>

          </person-group>

          <year>2012</year>

          <article-title><![CDATA[Evaluation of guideline recommendations on oral medications for type 2 diabetes mellitus: A systematic review.]]></article-title>

          <source>Ann. Intern Med.,</source>

          <volume>156</volume>

          <fpage>27</fpage>

          <lpage>36</lpage>

        </citation>

      </ref>


















      <ref id="1126207">

        <label>6</label>

        <citation citation-type="journal" xlink:type="simple">

          <person-group person-group-type="author">

            <name name-style="western">

              <surname>Dokken, B.,</surname>

              <given-names></given-names>

            </name>

          </person-group>

          <year>2012</year>

          <article-title><![CDATA[The kidney as a treatment target for type 2 diabetes.]]></article-title>

          <source>Diabetes Spect.,</source>

          <volume>25</volume>

          <fpage>29</fpage>

          <lpage>36</lpage>

        </citation>

      </ref>


















      <ref id="1126209">

        <label>7</label>

        <citation citation-type="journal" xlink:type="simple">

          <person-group person-group-type="author">

            <name name-style="western">

              <surname>Campbell, J.L., T.L. Hopman, J.A. Maxwell and Z. Nejedly,</surname>

              <given-names></given-names>

            </name>

          </person-group>

          <year>2000</year>

          <article-title><![CDATA[The Guelph PIXE software package III: Alternative proton database.]]></article-title>

          <source>Nucl. Instr. Methods Phys. Res. B: Beam Inter. Mater. Atoms,</source>

          <volume>170</volume>

          <fpage>193</fpage>

          <lpage>204</lpage>

        </citation>

      </ref>


















      <ref id="172186">

        <label>8</label>

        <citation citation-type="journal" xlink:type="simple">

          <person-group person-group-type="author">

            <name name-style="western">

              <surname>Chausmer, A.B.,</surname>

              <given-names></given-names>

            </name>

          </person-group>

          <year>1998</year>

          <article-title><![CDATA[Zinc, insulin and diabetes.]]></article-title>

          <source>J. Am. Coll. Nutr.,</source>

          <volume>17</volume>

          <fpage>109</fpage>

          <lpage>115</lpage>

        </citation>

      </ref>


















      <ref id="60058">

        <label>9</label>

        <citation citation-type="journal" xlink:type="simple">

          <person-group person-group-type="author">

            <name name-style="western">

              <surname>Grover, J.K., S. Yadav and V. Vats,</surname>

              <given-names></given-names>

            </name>

          </person-group>

          <year>2002</year>

          <article-title><![CDATA[Medicinal plants of India with anti-diabetic potential.]]></article-title>

          <source>J. Ethnopharmacol.,</source>

          <volume>81</volume>

          <fpage>81</fpage>

          <lpage>100</lpage>

        </citation>

      </ref>


















      <ref id="1126210">

        <label>10</label>

        <citation citation-type="journal" xlink:type="simple">

          <person-group person-group-type="author">

            <name name-style="western">

              <surname>Lempainen, J., R. Hermann, R. Veijola, O. Simell, M. Knip and J. Ilonen,</surname>

              <given-names></given-names>

            </name>

          </person-group>

          <year>2012</year>

          <article-title><![CDATA[Effect of the <I>PTPN22</I> and <I>INS</I> risk genotypes on the progression to clinical type 1 diabetes after the initiation of &beta;-cell autoimmunity.]]></article-title>

          <source>Diabetes,</source>

          <volume>61</volume>

          <fpage>963</fpage>

          <lpage>966</lpage>

        </citation>

      </ref>


















      <ref id="746708">

        <label>11</label>

        <citation citation-type="journal" xlink:type="simple">

          <person-group person-group-type="author">

            <name name-style="western">

              <surname>Nathan, D.M., J.B. Buse, M.B. Davidson, E. Ferrannini and R.R. Holman <i>et al</i>.,</surname>

              <given-names></given-names>

            </name>

          </person-group>

          <year>2009</year>

          <article-title><![CDATA[Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes.]]></article-title>

          <source>Diabetes Care,</source>

          <volume>32</volume>

          <fpage>193</fpage>

          <lpage>203</lpage>

        </citation>

      </ref>


















      <ref id="521299">

        <label>12</label>

        <citation citation-type="journal" xlink:type="simple">

          <person-group person-group-type="author">

            <name name-style="western">

              <surname>Papanikolaou, G. and K. Pantopoulos,</surname>

              <given-names></given-names>

            </name>

          </person-group>

          <year>2005</year>

          <article-title><![CDATA[Iron metabolism and toxicity.]]></article-title>

          <source>Toxicol. Applied Pharmacol.,</source>

          <volume>202</volume>

          <fpage>199</fpage>

          <lpage>211</lpage>

        </citation>

      </ref>


















      <ref id="300466">

        <label>13</label>

        <citation citation-type="journal" xlink:type="simple">

          <person-group person-group-type="author">

            <name name-style="western">

              <surname>Rajurkar, N.S. and M.M. Damame,</surname>

              <given-names></given-names>

            </name>

          </person-group>

          <year>1998</year>

          <article-title><![CDATA[Mineral content of medicinal plants used in the treatment of diseases resulting from urinary tract disorders.]]></article-title>

          <source>Applied Radiat. Isotopes,</source>

          <volume>49</volume>

          <fpage>773</fpage>

          <lpage>776</lpage>

        </citation>

      </ref>


















      <ref id="1126211">

        <label>14</label>

        <citation citation-type="journal" xlink:type="simple">

          <person-group person-group-type="author">

            <name name-style="western">

              <surname>Rautray, T.R., V. Vijayan and S. Panigrahi,</surname>

              <given-names></given-names>

            </name>

          </person-group>

          <year>2007</year>

          <article-title><![CDATA[Analysis of Indian pigment gallstones.]]></article-title>

          <source>Nucl. Instr. Methods Phys. Res. B: Beam Inter. Mater. Atoms,</source>

          <volume>255</volume>

          <fpage>409</fpage>

          <lpage>415</lpage>

        </citation>

      </ref>


















      <ref id="936817">

        <label>15</label>

        <citation citation-type="journal" xlink:type="simple">

          <person-group person-group-type="author">

            <name name-style="western">

              <surname>Ray, D.K., P.K. Nayak, T.R. Rautray, V. Vijayan and S. Jena,</surname>

              <given-names></given-names>

            </name>

          </person-group>

          <year>2004</year>

          <article-title><![CDATA[Elemental analysis of anti-diabetic medicinal plants using energy dispersive X-ray fluorescence technique.]]></article-title>

          <source>Indian J. Phys.,</source>

          <volume>78</volume>

          <fpage>103</fpage>

          <lpage>105</lpage>

        </citation>

      </ref>


















      <ref id="1126213">

        <label>16</label>

        <citation citation-type="journal" xlink:type="simple">

          <person-group person-group-type="author">

            <name name-style="western">

              <surname>Ray, D.K., P.K. Nayak, S.R. Panda, T.R. Rautray, V. Vijayan, C.C. Christopher and S. Jena,</surname>

              <given-names></given-names>

            </name>

          </person-group>

          <year>2006</year>

          <article-title><![CDATA[Particle induced X-ray emission studies of anti-diabetic medicinal plants.]]></article-title>

          <source>Int. J. PIXE,</source>

          <volume>16</volume>

          <fpage>47</fpage>

          <lpage>54</lpage>

        </citation>

      </ref>


















      <ref id="707569">

        <label>17</label>

        <citation citation-type="journal" xlink:type="simple">

          <person-group person-group-type="author">

            <name name-style="western">

              <surname>Rehder, D.,</surname>

              <given-names></given-names>

            </name>

          </person-group>

          <year>2003</year>

          <article-title><![CDATA[Biological and medicinal aspects of vanadium.]]></article-title>

          <source>Inorg. Chem. Commun.,</source>

          <volume>6</volume>

          <fpage>604</fpage>

          <lpage>617</lpage>

        </citation>

      </ref>


















      <ref id="1126214">

        <label>18</label>

        <citation citation-type="journal" xlink:type="simple">

          <person-group person-group-type="author">

            <name name-style="western">

              <surname>Sattar, S.A., B.S. Reddy, V.K. Rao, A.S. Pradeep and G.N. Raju <i>et al</i>.,</surname>

              <given-names></given-names>

            </name>

          </person-group>

          <year>2012</year>

          <article-title><![CDATA[Estimation of trace elements in some anti-epileptic medicinal plants by PIXE.]]></article-title>

          <source>J. Radioanal. Nucl. Chem.,</source>

          <volume>294</volume>

          <fpage>337</fpage>

          <lpage>341</lpage>

        </citation>

      </ref>


















      <ref id="568329">

        <label>19</label>

        <citation citation-type="journal" xlink:type="simple">

          <person-group person-group-type="author">

            <name name-style="western">

              <surname>Shaw, J.E., R.A. Sicree and P.Z. Zimmet,</surname>

              <given-names></given-names>

            </name>

          </person-group>

          <year>2010</year>

          <article-title><![CDATA[Global estimates of the prevalence of diabetes for 2010 and 2030.]]></article-title>

          <source>Diabetes Res. Clin. Pract.,</source>

          <volume>87</volume>

          <fpage>4</fpage>

          <lpage>14</lpage>

        </citation>

      </ref>


















      <ref id="1126215">

        <label>20</label>

        <citation citation-type="journal" xlink:type="simple">

          <person-group person-group-type="author">

            <name name-style="western">

              <surname>Schumann, K.,</surname>

              <given-names></given-names>

            </name>

          </person-group>

          <year>2006</year>

          <article-title><![CDATA[Dietary reference intakes for trace elements revisited.]]></article-title>

          <source>J. Trace Elem. Med. Biol.,</source>

          <volume>20</volume>

          <fpage>59</fpage>

          <lpage>61</lpage>

        </citation>

      </ref>


















      <ref id="151981">

        <label>21</label>

        <citation citation-type="journal" xlink:type="simple">

          <person-group person-group-type="author">

            <name name-style="western">

              <surname>Tiwari, A.K. and J.M. Rao,</surname>

              <given-names></given-names>

            </name>

          </person-group>

          <year>2002</year>

          <article-title><![CDATA[Diabetes mellitus and multiple therapeutic approaches of phytochemicals: Present status and future prospects.]]></article-title>

          <source>Curr. Sci.,</source>

          <volume>83</volume>

          <fpage>30</fpage>

          <lpage>38</lpage>

        </citation>

      </ref>






























      <ref id="12556">

        <label>22</label>

        <citation citation-type="journal" xlink:type="simple">

          <person-group person-group-type="author">

            <name name-style="western">

              <surname>Rajavashisth, T.B., M. Shaheen, K.C. Norris, D. Pan, S.K. Sinha, J. Ortega and T.C. Friedman,</surname>

              <given-names></given-names>

            </name>

          </person-group>

          <year>2012</year>

          <article-title><![CDATA[Decreased prevalence of diabetes in marijuana users: Cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) III.]]></article-title>

          <source>BMJ Open, Vol. 2.</source>

          <volume>2012</volume>

        </citation>

      </ref>






      <ref id="1126216">

        <label>23</label>

        <citation citation-type="journal" xlink:type="simple">

          <person-group person-group-type="author">

            <name name-style="western">

              <surname>Vaag, A. and S.S. Lund,</surname>

              <given-names></given-names>

            </name>

          </person-group>

          <year>2011</year>

          <article-title><![CDATA[Insulin initiation in patients with type 2 diabetes mellitus: Treatment guidelines, clinical evidence and patterns of use of basal versus premixed insulin analogues.]]></article-title>

          <source>Eur. J. Endocrinol.,</source>

          <volume>166</volume>

          <fpage>159</fpage>

          <lpage>170</lpage>

        </citation>

      </ref>






























      <ref id="12557">

        <label>24</label>

        <citation citation-type="journal" xlink:type="simple">

          <person-group person-group-type="author">

            <name name-style="western">

              <surname>Yeo, J., Y.M. Kang, S.I. Cho and M.H. Jung,</surname>

              <given-names></given-names>

            </name>

          </person-group>

          <year>2011</year>

          <article-title><![CDATA[Effects of a multi-herbal extract on type 2 diabetes.]]></article-title>

          <source>Chin. Med., Vol. 6.</source>

          <volume>2011</volume>

        </citation>

      </ref>




  </ref-list>

</article>

