Research Journal of Medicinal Plants1819-34552151-7924Science International10.3923/rjmp.2012.37.46Ocimum sanctum in Rats]]>Venu PrasadM.P. KhanumFarhath 1201261Ocimum sanctum L. is known for its medicinal properties and also has been considered sacred in India since Vedic times. The aqueous suspension of 70% alcoholic extract of Ocimum sanctum L. was investigated for antifatigue activity. Rats were subjected to Weight-loaded Forced Swim Test (WFST) every alternate day for 2 weeks. O. sanctum at a dosage of 150, 300 and 450 mg kg-1 b.wt. was administrated to rats every day. Swimming time, change in body weight, lipid peroxidation, Lactic Acid (LA), glycogen and blood biochemical parameters namely heamoglobin (Hb%), Blood Urea Nitrogen (BUN) and Creatine Kinase (CK) were evaluated as biomarkers of physical fatigue. The O. sanctum treatment was found to lower malondialdehyde (MDA) and lactic acid levels in liver and muscle tissues compared with control exercise group (p<0.05). Serum biochemical parameters viz., BUN and CK activity were also reduced as compared with control exercise group (p<0.05). The present study thus indicates that out of three studied treatments of O. sanctum (O. sanctum -150, 300 and 450); the O. sanctum at the dose of 300 mg kg-1 b.wt. showed better performance against fatigue when compared with other two treatments. As treatment at 300 mg kg-1 b.wt. facilitated the aerobic glucose metabolism and promote swimming time, suggesting that O. sanctum ameliorates the various impairments associated with physical fatigue.]]>Abdel-Azim, N.S., K.A. Shams, A.A.A. Shahat, M.M. El-Missiry, S.I. Ismail and F.M. Hammouda,20115136144Anbarasu, K. and G. Vijayalakshmi,2007Ocimum sanctum (Tulsi) extracts to benefit Indian rural population.]]>72M300M305Alessio, H.M. and A.H. Goldfrab,19886413331336Bhattacharya, K. and S. Ghosal,2000117Buege, J.A. and S.D. Aust,19781978pp: 302-310pp: 302-310Davis, J.M. and S.P. Bailey,1997294547Devi, P.U. and A. Ganasoundari,1995Ocimum sanctum.]]>33205208Dohm, G.L., E.B. Tapscott, H.A. Barakat and G.J. Kasperek,198355830833Gao, S.J. and D. Wu,2008289092Gupta, S.K., J. Prakash and S. Srivastava,2002Ocimun sanctun Linn. as a medicinal plant.]]>40765773Gupta, P., D.K. Yadav, K.B. Siripurapu, G. Palit and R. Maurya,2007Ocimum tanuiflorum with antistress activity.]]>7014101416Hemalatha, R., K.N. Babu, M. Karthik, R. Ramesh, B.D. Kumar and P.U. Kumar,2011Ocimum sanctum in myelosuppressed Swiss Albino mice.]]>62331Ishola, I.O. and R.B. Ashorobi,2007Cnestis ferruginea.]]>3295298Ishola, I.O., R.B. Ashorobi and O. Adeoluwa,2008Alchornea cordifolia.]]>1476480Jeba, R.C., R. Vaidyanathan and G. Rameshkumar,2011Ocimum sanctum in rat.]]>23338Joshi, H. and M. Parle,2006Ocimum sanctum Linn. in mice.]]>44133136Jung, C.H., H. Jung, Y.C. Shin, J.H. Park and C.Y. Jun et al.,2007113183187Karim, A., M.N. Sohail, S. Munir and S. Sattar,20117419439Kumar, G.P., R. Kumar and O.P. Chaurasia,20115685694Kumar, V., S. Mukhopadhyay, P.S. Bedi, G. Singh and P. Balakumar,20083 in exercise-induced apoptosis of rat skeletal muscle.]]>3361372Liu, J.,1995495768Marcondes, F.K., L.C. Vanderlei, L.L. Lanza and R.C. Spadari-Bratfisch,199674663669Mediratta, P.K., K.K. Sharma and S. Singh,2002Ocimum sanctum seed oil and its possible mechanism of action.]]>801520Malik, A.R., M.A.A. Siddique, P.A. Sofi and J.S. Butola,20115515530Miller, G.L.,195931426428Mishra, P. and S. Mishra,2011Ocimum sanctum extract against gram positive and gram negative bacteria.]]>6336341Nikinmaa, M.,1997200369380Oboh, F.O.J., H.I. Masodje and S.A. Enabulele,2009Ocimum gratissimum leaves.]]>9377380Passarella, S., L. de Bari, D. Valenti, R. Pizzuto, G. Paventi and A. Atlante,200858235693576Ravindran, R., S.D. Rathinasamy, J. Samson and M. Senthilvelan,2005Ocimum sanctum (Linn) treatment in albino rats.]]>98354360Blaylock, R.L.,19991117133Samson, J., R. Sheeladevi and R. Ravindran,2007Ocimum sanctum in noise exposure.]]>28679685Satyavati, G.V., A.K. Gupta and N. Tandon,1987Ocimum sanctum Linn. Medicinal Plants of India.]]>1987pp: 355-371pp: 355-371Singh, N., P. Verma, N. Mishra and R. Nath,19912399103Singh, S. and D.K. Majumdar,1999Ocimum sanctum (Holy Basil).]]>651319Sawhney, S.K. and R. Singh,20052nd Edn.,Pages: 452Pages: 452Scmbulingam, K., P. Sembulingam and A. Namasivayam,2005Ocimum sactum Linn. on the changes in central cholinergic system induced by acute noise stress.]]>96477482Keenoy, B.M., G. Moorkens, J. Vertommen and I. De Leeuw,20016820372049Tanaka, M., Y. Baba, Y. Kataoka, N. Kinbara and Y.M. Sagesaka, T. Kakuda and Y. Watanabe,200824599603Tanno, A.P., F.J. Bianchi, M.J.C.S. Moura and F.K. Marcondes,20027129732981Thaker, A.M. and J.V. Anjaria,198618171174Wang, J.J., M.J. Shieh, S.L. Kuo, C.L. Lee and T.M. Pan,200670247253Yu, B., Z.X. Lu, X.M. Bie, F.X. Lu and X.Q. Huang,2008226415421