Research Journal of Environmental Sciences1819-34122151-8238Academic Journals Inc.10.3923/rjes.2018.53.62Persea americana) Seed on Normal and Monosodium Glutamate-compromised Rats' Hepatic Histo-morphology and Serum Bio-functional Parameters]]>EgbuonuAnthony Cemaluk Chinedum OparaChinazum Immaculate AkachukwuDoris OnyedikachiUchechi Bliss 22018122Background and Objective: Continuous search for non-toxic natural products that could mitigate possible MSG-induced effects including on hepatic histo-morphology and functional capacity of animals. This study aimed to determine the effect of ethanolic extract of avocado pear (Persea americana) seeds (ASE) on normal and monosodium glutamate (MSG)-compromised rats liver. Methodology: After 14 days daily oral exposure of rats to ASE and MSG either alone or combined, changes in the rats liver histology and serum bio-indicators were assessed using standard protocols. Data were analyzed by one-way ANOVA using SPSS. Results: Serum alanine aminotransferase, ALT, (360.00 and 31.58%) and aspartate aminotransferase, AST, (176.77 and 04.46%) activities in the high-extract co-treated-group increased (p<0.05) above the others relative to control or MSG-group but decreased (p<0.05) more in ASE-group (07.03%, ALT, (43.50%, AST) relative to MSG-group. A similar trend was noted in the serum alkaline phosphatase (ALP) activity, protein concentration and the computed ratios (ALT:AST, AST:ALP, ALT:ALP and the respective corollary) of the rats while the highest increase and decrease in total bilirubin concentration relative to MSG-group was respectively in the medium-extract co-treated-group and in the ASE alone-group. Preserved hepatic histo-morphology with normal blood flow devoid of central vein congestion noted in the control and ASE alone-group contrasted the full central vein congestion in the MSG-group. Apparently reduced central vein congestion in the liver sections of rats co-exposed to MSG and low ASE dose was not sustained at either medium or high ASE concentration, seemingly confirming the serum chemistry observations. Conclusion: Thus, the study demonstrated a non-definitive influence of ASE alone and overriding adverse influence of MSG either alone or together with ASE on the hepatic histo-morphology and serum bio-functional indicators of the liver and perhaps other high metabolic organs.]]>Ezeanyika, L.U.S. and A.C.C. Egbuonu,20112657662Martin, J.G.P., E. Porto, C.B. Correa, S.M. de Alencar, E.M. da Gloria, I.S.R. Cabraland and L.M. de Aquino,201252736Parameswaran, I. and V.K. Murthin,2014Persea americana and Actinida deliciosa.]]>415Ezuruike, U.F. and J.M. Prieto,2014155857924Dreher, M.L. and A.J. Davenport,201353738750Alhassan, A.J., M.S. Sule, M.K. Atiku, A.M. Wudil, H. Abubakar and S.A. Mohammed,2012Persea americana) seed extract on alloxan induced diabetes rats.]]>2511Anaka, O.N., R.I. Ozolua and S.O. Okpo,2009Persea americana Mill (Lauraceae) on the blood pressure of sprague-dawley rats.]]>3485490Leite, J.J.G., E.H.S. Brito, R.A. Cordeiro, R.S.N. Brilhante and J.J.C. Sidrim et al.,2009Persea americana (Avocado) seed extracts.]]>42110113B.S. Nayak, S.S. Raju and A.V. Chalapathi-Rao,2008Persea americana (avocado) fruit: A preclinical study on rats.]]>17123125Ilegbedion, I.G., F.M. Onyije and O.O. Chibuike,201312413418Madiha, A.A., F.A.E. Hala and M.M.G. Ebtesam,201210209219Shi, Z., N.D. Luscombe-Marsh, G.A. Wittert, B. Yuan, Y. Dai, X. Pan and A.W. Taylor,2010104457463Egbuonu, A.C.C. and O.N. Osakwe,20112653656Thomas, M., K.S. Sujatha and S. George,2009Piper longum Linn. on monosodium glutamate induced oxidative stress in rats.]]>47186192Okwudiri, O.O., A.C. Sylvanus and I.A. Peace,20122111Nakanishi, Y., K. Tsuneyama, M. Fujimoto, T.L. Salunga and K. Nomoto et al.,2008304250Egbuonu, A.C.C., C.A. Ezeokonkwo, P.M. Ejikeme, O. Obidoa and L.U.S. Ezeanyika,201058995Egbuonu, A.C.C., O. Obidoa, C.A. Ezeokonkwo, P.M. Ejikeme and L.U.S. Ezeanyika,20109213311337Onaolapo, A.Y., T.J.M. Onaolapo, T.J. Mosaku, O.O. Akanji and O. Abiodun,20133294306Egbuonu, A.C.C.,2015Citrullus lanatus) rind and seed.]]>9160167Saidu, Y., L.S. Bilbis, M. Lawal, S.A. Isezuo, S.W. Hassan and A.Y. Abbas,2007Albizzia chevalieri harms (Leguminosae).]]>2224236Egbuonu, A.C.C., O. Obidoa, C.A. Ezeokonkwo, L.U.S. Ezeanyika and P.M. Ejikeme,2009830313035Ghouri, N., D. Preiss and N. Sattar,20105211561161Egbuonu, A.C.C.,20101912Egbuonu, A.C.C. and S.O. Oriji,2017Mangifera indica (mango) seed kernel mitigated monosodium glutamate-intoxicated rats’ kidney histology and bio-functions.]]>517Mbah, U.O. and A.C.C. Egbuonu,2017Solanum melongena Linn fruit mitigated monosodium glutamate-induced oxidative stress.]]>1818Mbah, U.O. and A.C.C. Egbuonu,2017Solanum melongena Linn) fruit ethanolic extract on monosodium glutamate-intoxicated rats' lipid profile, haematology and heart histology.]]>18110Egbuonu, A.C.C. and G.A. Ekwuribe,2017Mangifera indica (Mango) seed-kernel modulated serum lipid profile in monosodium glutamate-challenged rats.]]>57287Reitman, S. and S. Frankel,1957285663Egbuonu, A.C.C., A.E. Ogbu and L.U.S. Ezeanyika,201212253257Henry, R.J., D.C. Cannon and J.W. Winkelman,19742nd Edn.,pp: 33-35pp: 33-35Egbuonu, A.C.C. and D.C. Nzewi,2014Dioscorea dumetorum).]]>8231238Egbuonu, A.C.C., D.C. Nzewi and O.N.C. Egbuonu,2014Dioscorea dumetorum).]]>2014Egbuonu, A.C.C., D.C. Nzewi and O.N.C. Egbuonu,2014Dioscorea dumetorum) as influenced by soaking prior to oven-drying.]]>997103Afolayan, A.J. and M.T. Yakubu,2009Bulbine natalensis baker stem extract on the functional indices and histology of the liver and kidney of male Wistar rats.]]>12814820Yakubu, M.T., M.A. Akanji and A.T. Oladij,2008Fadogia agrestis stem on male rat kidney function indices.]]>19359367Soliman, A.M.,20115398408Kolawole, O.T.,201311115