Research Journal of Environmental Sciences1819-34122151-8238Academic Journals Inc.10.3923/rjes.2014.142.148Mus musculus)]]>OloyedeA.M. OgunlajaO. OgunlajaA. 3201483Adire and Kampala (Tie and dye) have been produced in Itoku, Abeokuta,
Ogun state-Nigeria for over a century. Large quantity of water has been involved
and effluents have been discharged into surrounding sources of water without
adequate treatment. The evaluation of the sub-chronic toxicity of the Adire
and Kampala textile effluents is done by investigating its effect on the weights,
histopathologic and haematologic indices in normal albino mice. Normal albino
mice of either sex weighing between 23 and 37 g were divided into five groups
of 10 animals each. Four concentrations were orally administered 1, 5, 25 and
50% while control animals received distilled water over 28 days. Animals were
weighed weekly and sacrificed after day 28. Organs were harvested, weighed and
subjected to histopathologic assessment. Blood samples were used for haematological
studies. The 30 and 50% mortality was observed in the groups administered 25
and 50% concentration, respectively and several signs of toxicity were observed
in other groups. Decreased organs and body weight, WBC, PCV and Hb significantly
different from control were observed. Histopathologic studies showed remarkable
distortion in the histo-architecture of the visceral organs, like alveoli disruption,
spleen pigmentation, tubular necrosis in kidney and hemorrhage in the heart.
The mortality observed, decreased haematologic indices, internal organs, body
weight and gross distortion in the histo-architecture of the visceral organs
are indications that the Adire and Kampala textile effluents contain
substances that are toxic to the animal physiology. These substances which may
have seeped into surrounding rivers and wells in Abeokuta town can cause severe
health malaise in the inhabitants of such area.]]>Baughman, G.L. and T.A. Perenich,19887183199Choudhary, A., R. Mangal and S. Gour,200831621Eremektar, G., H. Selcuk and S. Meric,2007211314320Hacioglu, N. and B. Dulger,2009819291937Kumari, V., N. Priyadarshani and M.C. Varma,2013Mus musculus.]]>23538Larsson, A., C. Haux and M.L. Sjobeck,19859250281Lee, G., J. Forester, F. Paraskevas, J. Greer and G. Rodgers,19991999pp: 27-63pp: 27-63Liber, K., L. Weber and C. Levesque,2005Salvelinus namaycush).]]>6111231133Mathur, N. and P. Bhatnagar,200728123126Mbagwu, H.O., R.A. Anene and O.O. Adeyemi,2007Mezoneuron benthamianum Baill (Caesalpiniaceae).]]>173541Novotny, C., N. Dias, A. Kapanen, K. Malachova, M. Vandrovcova, M. Itavaara and N. Lima,20066314361442Rosidah, M.F. Yam, A. Sadikun, M. Ahmad, G.A. Akowuah and M.Z. Asmawi,2009Gynura procumbens.]]>123244249Salami, T.,20012001Sharma, S., A. Kalpana, V.S. Shweta, P.K. Singh, S. Ramesh and K.P. Sharma,2007138185Weber, E.J. and N.L. Wolfe,19876911920Wepener, V., J.H. van Vuren and H.H. Du Preez,1992Tilapia sparrmanii (Cichlidae).]]>101375381Sinha, R. and D. D'Souza,2008Mus musculus.]]>32226Varma, M.C. and R. Pratap,2006Mus musculus.]]>11320